FORMULATION, DEVELOPMENT AND EVALUATION OF in-situ FLOATING GEL OF PREGABALIN

FORMULATION, DEVELOPMENT AND EVALUATION OF in-situ FLOATING GEL OF PREGABALIN

Registration ID: IJNRD_219558

Published ID: IJNRDTH00135

DOI: Click Here to Get

DR.B.V RAMANA , P.CHAITANYA , B.BALA KRISHNA , N.DINESH , B.MD. THOWSIF

FORMULATION, DEVELOPMENT AND EVALUATION OF in-situ FLOATING GEL OF PREGABALIN

Pregabalin (PRG), an analogue of gamma-aminobutyric acid, reduces the release of many neurotransmitters, including glutamate, and noradrenaline. It is used for the treatment of epilepsy; simple and complex partial convulsion. The present research work aims to ensure a high drug absorption by retarding the advancement of PRG formulation through the gastrointestinal tract. The work aims to design a controlled release PRG formulation which is administered as liquid and further gels in the stomach and floats in gastric juice. Materials and Methods: In situ gelling formulations were prepared using sodium alginate, calcium carbonate, sodium Bicarbonate, hydroxypropyl methylcellulose (HPMC) E-50M, and sodium bicarbonate. The prepared formulations were evaluated for solution viscosity, drug content, in vitro gelling studies, gel strength, and in vitro drug release. Results: The formulation containing 3% w/v sodium alginate and 0.6% w/v HPMC E-50 were considered optimum since it showed minimum floating lag time (18 s), optimum viscosity (287.3 cps). The optimized formulation follows first ordering Higuchi kinetic model with regression value 0.4767 representing diffusion mechanism of drug release. Conclusion: Floating in situ gelling system of PRG can be formulated using sodium alginate as a gelling polymer and calcium carbonate as a complexing agent to control the drug release for about 8 h for the treatment of epilepsy.

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"FORMULATION, DEVELOPMENT AND EVALUATION OF in-situ FLOATING GEL OF PREGABALIN", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 4, page no.865-914, April-2024, Available :https://ijnrd.org/papers/IJNRDTH00135.pdf

Volume 9 Issue 4, April-2024

Pages : 865-914

Paper Reg. ID: IJNRD_219558

Published Paper Id: IJNRDTH00135

Downloads: 000121170

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRDTH00135.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRDTH00135

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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