Formulation And Evaluation Of Floating Gastroretentive Microsphere Of Antiviral Agent (Acyclovir).

Registration ID: IJNRD_224841

Published ID: IJNRDTH00178

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Masarrat L. Ali, Gayatri Chinchulkar , Shubhangi Kotangale , Rani Rode , Sheikh Samir

Acyclovir, Drug delivery system, HPMC, Gastroretentive dosage forms.

This study focuses on the formulation and evaluation of floating gastroretentive microspheres containing the antiviral agent acyclovir. The aim is to enhance the bioavailability and therapeutic efficacy of acyclovir by prolonging its gastric residence time. Microspheres were prepared using the solvent evaporation method, employing different polymers such as ethyl cellulose, and carbopol 934P to achieve sustained release and buoyancy.Various formulations were developed by altering the polymer concentration and drug-to-polymer ratios. The prepared microspheres were evaluated for particle size, surface morphology, drug loading, entrapment efficiency, in vitro buoyancy, and in vitro drug release. Particle size analysis indicated that the microspheres were in the range of 150-300 micrometers. Scanning electron microscopy (SEM) revealed that the microspheres were spherical with a smooth surface.The drug entrapment efficiency of the microspheres ranged from 60% to 85%, and the buoyancy tests demonstrated that more than 75% of the microspheres remained floating for over 12 hours. In vitro drug release studies were conducted in simulated gastric fluid (pH 1.2) using a USP type II dissolution apparatus. The results showed a sustained release of acyclovir from the microspheres, with drug release extending up to 12 hours, depending on the formulation. The optimized formulation, which contained HPMC as the primary polymer, exhibited a desirable balance between buoyancy and sustained release, with an entrapment efficiency of 82% and 88% of the microspheres remaining buoyant for 12 hours. The release kinetics followed a Non-fiction diffusion model, indicating that drug release was controlled by both diffusion and polymer erosion. In conclusion, the floating gastroretentive microspheres of acyclovir formulated in this study showed promising potential for enhancing the bioavailability and sustained delivery of the drug, thereby potentially improving its therapeutic effectiveness in the treatment of viral infections. Further in vivo studies are warranted to confirm these findings.

Published Paper   E-Certificate

Masarrat L. Ali, Gayatri Chinchulkar , Shubhangi Kotangale , Rani Rode , & Sheikh Samir (July-2024). Formulation And Evaluation Of Floating Gastroretentive Microsphere Of Antiviral Agent (Acyclovir).. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), 653-701. https://ijnrd.org/papers/IJNRDTH00178.pdf

Volume 9 Issue 7, July-2024

Pages : 653-701

Paper Reg. ID: IJNRD_224841

Published Paper Id: IJNRDTH00178

Downloads: 000122049

Research Area: Pharmacy

Author Type: Indian Author

Country: Nagpur , Maharashtra , India

Published Paper PDF: https://ijnrd.org/papers/IJNRDTH00178.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRDTH00178

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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