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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | A Review on Therapeutic Applications of GSK-3 beta Inhibitors |
| Authors Name: | Anu Jayamol Mathew , Aiswarya Suresh , Anu Yousef , Dr. Deepa Jose |
| Download E-Certificate: | Download |
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IJNRD_180575
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| Published Paper Id: | IJNRD2203010 |
| Published In: | Volume 7 Issue 3, March-2022 |
| DOI: | |
| Abstract: | Abstract : Glycogen synthase kinase 3 beta (GSK-3 beta), which is a serine/threonine kinase was initially identified because of its key role in the regulation of glycogen synthesis. But it is now well-established that GSK-3 performs critical functions in many cellular processes, such as apoptosis, tumor growth, cell invasion, and metastasis. Many human disorders, including cancer, have been linked to abnormal GSK-3 activity, underlining its therapeutic promise as a cancer target. [29]. There is conflicting evidence on the effect of GSK-3 inhibition on cancer cell development due to multiple methods through which GSK-3 may influence carcinogenesis. It can act as a tumor promoter as well as a tumor suppressor in different types of cancers [14]. However, it is found that combination of GSK-3 beta inhibitors with chemotherapeutic agents can significantly reduce the resistance of various tumor cells towards the chemotherapy. In the last few years, many GSK-3 inhibitors have been developed, and some are currently being tested in clinical trials [16]. Indazoles are nitrogen-based heterocyclic chemicals that posses many types of biological activities and representatives of this class of pharmacological agents are widely used as antibacterial, anti-inflammatory, anti-HIV, Antiprotozoal and antimalarial agents. Recent studies are showing promising activity of indazole derivatives as anticancer agents. |
| Keywords: | Glycogen Synthase Kinase 3 Beta (GSK 3 Beta), Indazole Derivatives, GSK 3 Beta Inhibitors, Cancer, Alzheimer’s Disease, Diabetes |
| Cite Article: | "A Review on Therapeutic Applications of GSK-3 beta Inhibitors", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 3, page no.94-103, March-2022, Available :http://www.ijnrd.org/papers/IJNRD2203010.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2203010 Registration ID: 180575 Published In: Volume 7 Issue 3, March-2022 DOI (Digital Object Identifier): Page No: 94-103 Country: Ernakulam, Kerala, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2203010 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2203010 |
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ISSN: 2456-4184
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