Development and Validation of RP-HPLC method for determination of fosinopril sodium and Hydrochlorothiazide in Bulk and in tablet
Miss. Sayali Milind Patil
, Mr. Anup R. Jawale , Mr. Sachin S. Rane , Dr. Rajesh Y. Chaudhari , Dr. Vijay R. Patil
Fosinopril Sodium, Hydrochlororthiazide, Validation, RP-HPLC, Simultaneous Estimation.
This assay method was Development and Validation of RP-HPLC Method for Determination of Fosinopril Sodium and Hydrochlororthiazide in Bulk and in tablets. They were both drugs separated by using RP-HPLC on a RP- Agilent C18 (250 mm ×4.6 mm I.D.) with particle size 5 µm was selected. On the basis of literature survey the mobile phase was acetonitrile and phosphate buffer was selected at 0.7 ml/min. The UV detector was operated the overlain spectra 233 nm was selected for the estimation of both drugs. Linearity, accuracy, precision, Ruggedness and System suitability test was found to be acceptable concentration ranges 12.5 – 62.5μg/ml for Hydrochlororthiazide and 10-50μg/ml for Fosinopril Sodium with a R20.999 and 0.999 values respectively, in this mixture of drugs.
"Development and Validation of RP-HPLC method for determination of fosinopril sodium and Hydrochlorothiazide in Bulk and in tablet", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 3, page no.304-311, March-2022, Available :https://ijnrd.org/papers/IJNRD2203036.pdf
Volume 7
Issue 3,
March-2022
Pages : 304-311
Paper Reg. ID: IJNRD_180646
Published Paper Id: IJNRD2203036
Downloads: 000118811
Research Area: Pharmacy
Country: Jalgaon, Maharashtra, India
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJNRD (IJ Publication) Janvi Wave
