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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | DEVELOPMENT AND VALIDATION OF A NEW STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TADALAFIL AND DAPOXETINE |
| Authors Name: | Neha tarinnum , N.Harshitha , Om Sai N , P.Sridevi , Vinutha kommineni, M.Bhagavan Raju |
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IJNRD_181334
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| Published Paper Id: | IJNRD2205059 |
| Published In: | Volume 7 Issue 5, May-2022 |
| DOI: | |
| Abstract: | A new stability indicating RP HPLC method has been developed and validated for simultaneous estimation of Tadalafil and Dapoxitine in bulk and dosage forms. The method involves separation on Xterra C18 column (250mm x 4.6mm x5µm particle size). The optimized mobile phase consists of 0.1% OPA (pH 2.8) and Methanol (45:55v/v) with a flow rate of 1ml/min and UV detection at 229mn. Retention time was 2.78 min (Tadalafil), 3.71 min (Dapoxitine). Linearity range was 20-100 ug/ml (Tadalafil), 60-300 ug/ml (Dapoxitine). Accuracy was in the range of 96.92-100.35% for both drugs. Precision was 0.8% and 0.5% for Tadalafil and Dapoxitine. LOD and LOQ are 0.42ug/ml and 1.38 ug/ml for Tadalafil, 0.27ug/ml and 0.89ug/ml for Dapoxitine. The method developed is more sensitive, accurate and precise than the methods reported earlier. Retention time and run time were also less and hence the method is economical. When applied for tablet assay, drug content was within 98.55-101.4 % of labelled content. Forced degradation studies indicated the suitability of the method for stability studies. |
| Keywords: | Tadalafil and Dapoxitine, RP-HPLC Method, Simultaneous estimation, Validation, Forced degradation studies. |
| Cite Article: | "DEVELOPMENT AND VALIDATION OF A NEW STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TADALAFIL AND DAPOXETINE", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 5, page no.553-561, May-2022, Available :http://www.ijnrd.org/papers/IJNRD2205059.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2205059 Registration ID: 181334 Published In: Volume 7 Issue 5, May-2022 DOI (Digital Object Identifier): Page No: 553-561 Country: -, -, - Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2205059 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2205059 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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