FORMULATION, EVALUATION AND ANTIMICROBIAL ACTIVITY OF EVOLVULUS ALSINOIDES CREAM
Athulya
, Ashna Aji Haneef , Ashly S Abraham , Anjana S , Abini Daniel M, Ansa Mathew
Evolvulus alsinoides (EA); Cream; Fusion method; Brookfield viscometer; Antimicrobial activity; Lawn culture; Agar diffusion method; Muller Hinton Agar (MHA); Staphylococcus aureus; Escherichia coli.
Evolvulus alsinoides, commonly known as dwarf morning-glory and slender dwarf morning- glory, is flowering plant from the family Convolvulaceae. Traditionally this plant is used as blood purifier, brain tonic, an antimicrobial agent and for memory loss. This work is done for determining whether the cream prepared by the aqueous extract of Evolvulus alsinoides has antimicrobial activity. The dried plant leaves are extracted using water as the solvent. The extractive value is calculated and was found to be 12.5%𝑤⁄𝑤. The phytochemical screening of
the extract was performed and it contains slight amount of glycosides, carbohydrates, proteins, alkaloids and tannins. Then using that aqueous extract, a cream was formulated and its evaluation was carried out. From the evaluation the cream was found to be light brown in color with a characteristic odour and have smooth texture. pH and viscosity of the cream are 5.58 and 13254mpas respectively. Cream was homogeneous by its visual appearance with a smooth and good consistency. On application, the cream was non-slippery, smooth and easily removable , also does not show any irritation on skin. After that the antimicrobial activity of the cream was tested using agar well diffusion method. Gentamicin was used as the standard reference drug. The antimicrobial sensitivity was determined using zone of inhibition. In our study, the cream containing aqueous extract displayed antimicrobial activity against Staphylococcus aureus and Escherichia coli. The cream was found to be more active against gram-negative (Escherichia coli) bacteria. The identified phytochemical compounds viz., glycosides, tannins and alkaloids may be responsible for the antimicrobial activity of Evolvulus alsinoides.
"FORMULATION, EVALUATION AND ANTIMICROBIAL ACTIVITY OF EVOLVULUS ALSINOIDES CREAM ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 6, page no.178-191, June-2022, Available :https://ijnrd.org/papers/IJNRD2206019.pdf
Volume 7
Issue 6,
June-2022
Pages : 178-191
Paper Reg. ID: IJNRD_181684
Published Paper Id: IJNRD2206019
Downloads: 000118833
Research Area: Engineering
Country: -, -, India
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJNRD (IJ Publication) Janvi Wave
