Visible Spectrophotometri determination of Valsartan in Pharmaceutical Formulations
Spectrophotometry, Valsartan, ion-pair complex, Beer-Lambert's law,methylene blue, U.S. Pharmacopeia guidelines.
A simple, rapid, sensitive, and accurate extractive spectrophotometric method has been developed for the determination of Valsartan in pure forms as well as their pharmaceutical dosage forms. The method depends on the formation of an intensely colored ion-pair complex between the acidic drug and methylene blue in alkaline medium The complex is stable and extractable into methylene chloride. All parameters were optimized. Beer-Lambert's law was obeyed in concentrations ranging from 0.5.-3.0 ml, 200 µg/ml. Statistical analysis of the calibration data was carried out, and correlation coefficients were in the range from 0.9996 to 0.9998. The developed method was fully validated according to International Conference on Harmonization guidelines, and complied with U.S. Pharmacopeia guidelines. The proposed method was applied to the analysis of the investigated drugs in their pharmaceutical formulations, and good recoveries were obtained. The results obtained were compared with those of reported and official methods, and no significant differences were found with t- and F-tests. The method is applied successfully for the estimation Valsartan in tablet form without the interference of excipients.
"Visible Spectrophotometri determination of Valsartan in Pharmaceutical Formulations", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 6, page no.198-203, June-2022, Available :https://ijnrd.org/papers/IJNRD2206021.pdf
Volume 7
Issue 6,
June-2022
Pages : 198-203
Paper Reg. ID: IJNRD_181569
Published Paper Id: IJNRD2206021
Downloads: 000118830
Research Area: Chemistry
Country: Vizianagaram, Andhrapradesh, India
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJNRD (IJ Publication) Janvi Wave
