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ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
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Impact Factor : 8.76

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Paper Title: Visible Spectrophotometri determination of Valsartan in Pharmaceutical Formulations
Authors Name: Dr. K.Sandhyarani
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Published Paper Id: IJNRD2206021
Published In: Volume 7 Issue 6, June-2022
Abstract: A simple, rapid, sensitive, and accurate extractive spectrophotometric method has been developed for the determination of Valsartan in pure forms as well as their pharmaceutical dosage forms. The method depends on the formation of an intensely colored ion-pair complex between the acidic drug and methylene blue in alkaline medium The complex is stable and extractable into methylene chloride. All parameters were optimized. Beer-Lambert's law was obeyed in concentrations ranging from 0.5.-3.0 ml, 200 µg/ml. Statistical analysis of the calibration data was carried out, and correlation coefficients were in the range from 0.9996 to 0.9998. The developed method was fully validated according to International Conference on Harmonization guidelines, and complied with U.S. Pharmacopeia guidelines. The proposed method was applied to the analysis of the investigated drugs in their pharmaceutical formulations, and good recoveries were obtained. The results obtained were compared with those of reported and official methods, and no significant differences were found with t- and F-tests. The method is applied successfully for the estimation Valsartan in tablet form without the interference of excipients.
Keywords: Spectrophotometry, Valsartan, ion-pair complex, Beer-Lambert's law,methylene blue, U.S. Pharmacopeia guidelines.
Cite Article: "Visible Spectrophotometri determination of Valsartan in Pharmaceutical Formulations", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 6, page no.198-203, June-2022, Available :http://www.ijnrd.org/papers/IJNRD2206021.pdf
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ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID:IJNRD2206021
Registration ID: 181569
Published In: Volume 7 Issue 6, June-2022
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Page No: 198-203
Country: Vizianagaram, Andhrapradesh, India
Research Area: Chemistry
Publisher : IJ Publication
Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2206021
Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2206021
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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