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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | PREPARATION AND EVALUATION OF TRANSDERMALDRUG DELIVERY SYSTEM CONTAINING AN HYPERTENSIVE DRUG |
| Authors Name: | Mr. Pradeep bansal , Dr. Akhilesh Kumar singhai , Mr. Mahadev kanere |
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IJNRD_181950
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| Published Paper Id: | IJNRD2207018 |
| Published In: | Volume 7 Issue 7, July-2022 |
| DOI: | |
| Abstract: | The aim of the present study was to prepare and evaluate transdermal patches of Metoprolol Tartrate using sodium alginate and xanthan gum as biopolymers to minimize adverse effects associated with oral administration. Transdermal films of Metoprolol Tartrate with sodium alginate / xanthan gum by varying the blend ratios were prepared by solvent casting method. FTIR and DSC were studied to assess any interaction between the drug and the polymers. Drug loaded films were evaluated for physicochemical characteristics such as physical appearance, thickness, weight uniformity, folding endurance, % moisture absorption studies, , drug content uniformity, tensile strength, and in vitro diffusion was determined by Franz diffusion cell. The patches were tested for their potential to cause skin irritation in rats. Thin, flexible, smooth and transparent films of Metoprolol Tartrate was obtained with sodium alginate/xanthan gum blends. The FT-IR and DSC studies confirmed no interaction between the drug and polymers. Thickness, Tensile strength, folding endurance and % elongation were found to be uniform and reproducible. |
| Keywords: | Metoprolol Tartrate, Sodium alginate, Xanthan gum, Transdermal patch, Transdermal film. |
| Cite Article: | "PREPARATION AND EVALUATION OF TRANSDERMALDRUG DELIVERY SYSTEM CONTAINING AN HYPERTENSIVE DRUG", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 7, page no.138-154, July-2022, Available :http://www.ijnrd.org/papers/IJNRD2207018.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2207018 Registration ID: 181950 Published In: Volume 7 Issue 7, July-2022 DOI (Digital Object Identifier): Page No: 138-154 Country: -, -, - Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2207018 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2207018 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
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