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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | FORMULATION AND INVITRO EVALUATION OF LIPOSOMAL DRUG DELIVERY SYSTEM OF NYSTATIN |
| Authors Name: | Mr. Ravi Shrivastav , Mr. Firoz Khan , Mr. Abdul Wajid Ali , Dr. C.K.Tyagy , Dr. Prabhakar Budholiya |
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IJNRD_182354
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| Published Paper Id: | IJNRD2208023 |
| Published In: | Volume 7 Issue 8, August-2022 |
| DOI: | |
| Abstract: | Nystatin is widely used for the treatment of fungal disease. The intention of the present study was to formulate Nystatin liposomes for a sustained drug delivery system. It have the advantages of dose reduction, less dosing frequency, minimize the side effect, prolong the action of drug and thus achieve better patient compliance. The liposomes were prepared by physical dispersion and ether injection method. Soya lecithin and cholesterol were used for encapsulating the drug, it facilitates to release the medicaments in sustained manner. Chloroform, ether and methanol were used as a solvent. Phosphate buffer pH 6.8 was used as a hydration medium for loading the drug. The final liposome was evaluated in various quality parameters of drug entrapment efficiency, morphological analysis, particle size analysis, in-vitro drug release studies and stability studies. In the two methods of Nystatin liposome formulation the physical dispersion method showed prolonged action when compared to ether injection method. In the parameters of drug entrapment and stability physical dispersion method was shows better results. |
| Keywords: | Physical dispersion, ether injection, soya lecithin, cholesterol, morphological analysis, Nystatin. |
| Cite Article: | "FORMULATION AND INVITRO EVALUATION OF LIPOSOMAL DRUG DELIVERY SYSTEM OF NYSTATIN", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 8, page no.193-206, August-2022, Available :http://www.ijnrd.org/papers/IJNRD2208023.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2208023 Registration ID: 182354 Published In: Volume 7 Issue 8, August-2022 DOI (Digital Object Identifier): Page No: 193-206 Country: -, -, - Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2208023 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2208023 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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