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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Protective effect of sodium thiosulfate (hydrogen sulfide donor) against the pathological alterations in thyroid and testicular glands induced by ionizing gamma- radiation and/or cyclophosphamide in male rats. |
| Authors Name: | Ashraf kassem , Eman FS Taha , Azza Hassan , Ahmed H. Osman |
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IJNRD_182465
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| Published Paper Id: | IJNRD2208093 |
| Published In: | Volume 7 Issue 8, August-2022 |
| DOI: | |
| Abstract: | Background: Radiation therapy (RT) alone or in combination with chemotherapy, surgery or both is a major treatment option for solid malignancies. Sodium thiosulfate (STS), a donor of H2S, is a water-soluble inorganic sodium slat that has antioxidant and anti-inflammatory properties. Methods: Rats of all groups received STS for 14 days before treatment with cyclophosphamide and/or ionizing gamma radiation. The normal control rats received saline only. The other groups were then treated with cyclophosphamide (50mg/kg/wk. for 3 wk.) or exposed to gamma radiation (3 Gy/wk. for 3 weeks up to a total cumulative dose of 9 Gy). Then all groups received STS three times per week for 3 successive weeks during CYP and/or exposure to gamma- radiation. Results: STS reduced malondialdehyde (MDA) and elevated superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and reduced glutathione (GSH). Additionally, STS elevated the reduced gonadotropin, follicle-stimulating hormone (FSH) and the male sex hormone, testosterone. STS elevated thyroid hormones, triiodothyronine (T3) and thyroxine (T4). Furthermore, STS reduced the pathological deteriorations of testicular seminiferous tubules and thyroid follicles which reflect on caspase-3 and TNF-α histological markers. Conclusion: This study reveals that STS exerted protective effect confirmed by attenuation of oxidative stress and apoptosis and amelioration of the histopathological changes of both thyroid and testicular glands. |
| Keywords: | Cyclophosphamide, Sodium thiosulphate, ionizing gamma radiation, histopathology, thyroid and testis |
| Cite Article: | "Protective effect of sodium thiosulfate (hydrogen sulfide donor) against the pathological alterations in thyroid and testicular glands induced by ionizing gamma- radiation and/or cyclophosphamide in male rats.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 8, page no.871-885, August-2022, Available :http://www.ijnrd.org/papers/IJNRD2208093.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2208093 Registration ID: 182465 Published In: Volume 7 Issue 8, August-2022 DOI (Digital Object Identifier): Page No: 871-885 Country: -, -, - Research Area: Pathology Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2208093 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2208093 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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