INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
The aim of present work was to formulate thermosensitive in situ gel of carbamazepine (CBZ), an anti-epileptic agent. In situ nasal gel of CBZ was formulated by cold method using Pluronic F68 and Pluronic F127 as thermoreversible stimuli sensitive polymer along with two different grades of hydroxypropyl methyl cellulose as mucoadhesive polymer. It is thought that the thermo-reversion and mucoadhesion would synergistically enhance the residence time of the drug in the nasal cavity and also impart better penetration of the drug to brain for the site-specific activity. The sustained release obtained from the viscous gel makes the treatment even better especially in the chronic epileptic conditions like tonic-clonic seizures. The prepared formulations were evaluated for pH, clarity, in vitro gelation, gelling strength, mucoadhesion, in vitro drug release and accelerated stability studies. Results have shown that final batches of in situ gels were having desired gelation temperature to provide pourable ‘Sol’ form at room temperature and ‘Gel’ form in the nasal cavity with a good gel strength and mucoadhesion required for nasal retention. Formulations showed polymer concentration dependent drug release retardation over a period of 6 hrs.
"OPTIMIZATION OF THERMOREVERSIBLE NASAL GEL OF CARBAMAZEPINE FOR BETTER CONTROL IN CHRONIC EPILEPSY", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 9, page no.142-146, September-2022, Available :http://www.ijnrd.org/papers/IJNRD2209015.pdf
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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