INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
The main aim of the present study is to formulate an effective ocular inserts of Diclofenac sodium, which can produce a better ocular therapy against ocular infections by increased bioavailability through increased drug-eye contact time and controlling the trans-corneal permeation of drug. We intend to optimize the formulation to show constant release of drug for maintenance of dose over a prolonged period of time. For this purpose we prepared Diclofenac sodium ocular inserts formulations by use of different polymers, HPMC, Eudragit L100, Polyvinyl alcohol at various concentrations and dibutyl phthalate has plasticiser.The prepared formulations were evaluated for various physical and analytical parameter related to appearance, durability, uniformity of drug contents, in-vitro and in-vivo release of drug and for stability. ocular inserts of Diclofenac sodium were prepared by solvent casting method followed by preparing the drug reservoir film and rate controlling membrane separately. Evaluation of ocular inserts for weight and thickness variation were carried out.From current study we can conclude that by using different polymer in rate controlling membrane of an ocusert, release rate of drug from ocusert can be controlled or altered.
"FORMULATION AND EVALUATION OF OCULAR INSERTS OF DICLOFENAC SODIUM FOR CONTROLLED RELEASE DRUG DELIVERY", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 9, page no.262-272, September-2022, Available :http://www.ijnrd.org/papers/IJNRD2209031.pdf
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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