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ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
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Authors Name: Dhanapuram Akhila Banu , Kallu golla dinesh , Gopi Mareedu , Vivek B , Velmurugan C
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Published Paper Id: IJNRD2209134
Published In: Volume 7 Issue 9, September-2022
Abstract: Sitagliptin is given as an oral antidiabetic drug to treat Diabetes Mellitus. Himplasia may be co-prescribed along with sitagliptin to treat benign prostate hyperplasia. As such no information is available regarding the interaction taking place between sitagliptin and himplasia. Hence the present work has been aimed to find out the interaction with among the above said drugs in rodent model. Studies were conducted in normal and alloxan induced diabetic rats with oral doses of 9 mg / kg B.W of sitagliptin, and 54 mg /k g of himplasia and their combinations with adequate washout periods in between the treatments. Blood samples were collected at regular time intervals in rats through retro orbital puncture. All the blood samples were analyzed for blood glucose by GOD / POD method in pharmacodynamic studies and the serum sitagliptin concentrations were estimated by UV Spectrophotometry. Serum insulin was estimated by chemiluminescence assay. Sitagliptin showed hypoglycemic action in both normal and diabetic rats and the peak action was observed at 6 h. Hypoglycemia was observed with himplasia at 4th hour and the combination of sitagliptin and himplasia showed synergestic response in blood glucose levels. The serum sitagliptin concentrations were not altered by the co-administration of drugs. A serum insulin level was potentiated by himplasia co-administered with sitagliptin. Thus it could be concluded that the co-prescription of himplasia should be taken for clinical benefits in diabetic patients. However, further studies should be carried out in non rodent species and in clinical settings to confirm the beneficial effect of Himplasia coprescription with Sitagliptin.
Keywords: Diabetes mellitus, Sitagliptin, Himplasia, Interactions, Insulin, Estimation
Cite Article: "STUDY OF PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTION OF HIMPLASIA WITH SITAGLIPTIN IN RATS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 9, page no.1141-1152, September-2022, Available :http://www.ijnrd.org/papers/IJNRD2209134.pdf
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ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID:IJNRD2209134
Registration ID: 183089
Published In: Volume 7 Issue 9, September-2022
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Page No: 1141-1152
Country: Bangalore, Tamil Nadu, Karnataka
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2209134
Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2209134
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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