INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
New compounds were designed based on docking studies. GLIDE (Grid-based ligand docking with energetics, version autodock vina 1.5.7) was used to dock all the designed pyrazole containing coumarin derivatives within the binding site (PDB ID 4cv0). Docking based synthesis of coumarin contain pyrazoline derivatives, being used as potential medicinal agents, 3-Acetyl-2H-chromen-2one (I) was prepared by Knoevenagel condensation of salicylaldehyde with ethyl acetoacetate in presence of piperidine. A series of 3-[(2E)-3-substituted-prop-2-enoyl]-2H-chromen-2-one derivatives (II A-H) were prepared by Claisen-Schmidt condensation of 3-acetyl coumarin with aromatic aldehydes. Treatment of 3-substituted cinnamoyl coumarin with hydrazine hydrate in the presence of ethanol gave [5-substitutedphenyl]-4, 5-dihydro-1H pyrazol-3-yl]-2H-chromen-2-one (III A-H). Title compound were synthesized by conventional method. The structures of the newly synthesized compounds were confirmed by FT-IR and 1H-NMR spectroscopy. All the synthesized compounds were tested for their antibacterial activities using filter paper disc method. The antibacterial activity screening revels that the compound 3A, 3B and 3C are promising against S. aureus and E.coli. show moderate activity as that of standard amikacin against gram positive and gram-negative bacteria.
"DESIGN SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN DERIVATIVES AS AN ANTIMICROBIAL AGENTS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 9, page no.1590-1598, September 2022, Available :http://www.ijnrd.org/papers/IJNRD2209189.pdf
Downloads:
000118746
ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Facebook Twitter Instagram LinkedIn