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IJNRD
INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
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Impact Factor : 8.76

Issue per Year : 12

Volume Published : 7

Issue Published : 79

Article Submitted : 4920

Article Published : 2292

Total Authors : 5584

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Paper Title: DESIGN SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN DERIVATIVES AS AN ANTIMICROBIAL AGENTS
Authors Name: Mr. Mukesh Pawar , Dr. Govind Nayak , Dr. Parul Mehta , Dr. Shivakant Shukla
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IJNRD_183239
Published Paper Id: IJNRD2209189
Published In: Volume 7 Issue 9, September-2022
DOI:
Abstract: New compounds were designed based on docking studies. GLIDE (Grid-based ligand docking with energetics, version autodock vina 1.5.7) was used to dock all the designed pyrazole containing coumarin derivatives within the binding site (PDB ID 4cv0). Docking based synthesis of coumarin contain pyrazoline derivatives, being used as potential medicinal agents, 3-Acetyl-2H-chromen-2one (I) was prepared by Knoevenagel condensation of salicylaldehyde with ethyl acetoacetate in presence of piperidine. A series of 3-[(2E)-3-substituted-prop-2-enoyl]-2H-chromen-2-one derivatives (II A-H) were prepared by Claisen-Schmidt condensation of 3-acetyl coumarin with aromatic aldehydes. Treatment of 3-substituted cinnamoyl coumarin with hydrazine hydrate in the presence of ethanol gave [5-substitutedphenyl]-4, 5-dihydro-1H pyrazol-3-yl]-2H-chromen-2-one (III A-H). Title compound were synthesized by conventional method. The structures of the newly synthesized compounds were confirmed by FT-IR and 1H-NMR spectroscopy. All the synthesized compounds were tested for their antibacterial activities using filter paper disc method. The antibacterial activity screening revels that the compound 3A, 3B and 3C are promising against S. aureus and E.coli. show moderate activity as that of standard amikacin against gram positive and gram-negative bacteria.
Keywords: Docking, 3-Acetyl coumarin, Pyrazoline, hydrazine hydrate, Antibacterial activity
Cite Article: "DESIGN SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN DERIVATIVES AS AN ANTIMICROBIAL AGENTS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 9, page no.1590-1598, September 2022, Available :http://www.ijnrd.org/papers/IJNRD2209189.pdf
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ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID:IJNRD2209189
Registration ID: 183239
Published In: Volume 7 Issue 9, September-2022
DOI (Digital Object Identifier):
Page No: 1590-1598
Country: Bhopal, Bhopal, Madhya Pradesh, India
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2209189
Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2209189
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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