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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | FORMULATION AND EVALUATION OF TENOXICAM BUCCAL PATCHES FOR ARTHRITIC PAIN |
| Authors Name: | Dr. Wajid Chaus. , Atiya shaikh , Rajesh Raut , Sneha Khandale , Priya Deshmukh |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_183372
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| Published Paper Id: | IJNRD2210035 |
| Published In: | Volume 7 Issue 10, October-2022 |
| DOI: | |
| Abstract: | The main objective of the present study was to improve the bioavailability of Tenoxicam and decrease the frequency of dosage form administration by mucoadhesive drug delivery system. Tenoxicam is an NSAIDS belonging to the class non selective cox-2 inhibitor, well known to cause gastrointestinal disorders and renal effects when given orally. A buccal patch for systemic administration of Tenoxicam in oral cavity were developed using polymers chitosan, sodium alginate, Gelatin, in order to deliver the drug to the particular region of the body for extended period of time, maximizing the drug availability, minimize the adverse effects, avoiding the first pass metabolism and thereby improving patient compliance. The formulated patches were evaluated for Mass uniformity and thickness uniformity, folding endurance, Drug content uniformity, Measurement of surface pH, Swelling index, Tensile strength, bioadhesion test, In vitro residence time, In vitro membrane permeation studies. Drug polymer compatibility studies were carried out by FTIR. & shows drug is compatible with polymers. The in vitro drug releases and in-vitro drug permeation studies showed that drug was released from the patches and permeated through the porcine buccal mucosa and hence the formulated buccal patches possibly permeate through the human buccal membrane also. |
| Keywords: | Tenoxicam, Gelatin, sodium alginate, Chitosan, gum patches, Mucoadhesive drug delivery. |
| Cite Article: | "FORMULATION AND EVALUATION OF TENOXICAM BUCCAL PATCHES FOR ARTHRITIC PAIN", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 10, page no.287-295, October-2022, Available :http://www.ijnrd.org/papers/IJNRD2210035.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2210035 Registration ID: 183372 Published In: Volume 7 Issue 10, October-2022 DOI (Digital Object Identifier): Page No: 287-295 Country: Latur, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2210035 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2210035 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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