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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Evaluation of Hyaluronidase activity of proprietary date seed extract (SesZenNHA™) for skin health applications |
| Authors Name: | Ms. Sneha Badak , Ms.Ratna Upadhyay , Mr. Mihir Gadani , Ms. Supriya Raut |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_183339
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| Published Paper Id: | IJNRD2210053 |
| Published In: | Volume 7 Issue 10, October-2022 |
| DOI: | |
| Abstract: | Hyaluronic Acid or Hyaluronan is a glycosaminoglycan that is present in various connective and epithelial tissues. It increases viscosity of the fluid in synovial joints to reduce friction between bones. HA is a major component of the skin. When skin is exposed to UV, hyaluronin is degraded and skin cells reduce production of HA. Hyaluronic acid is degraded by hyaluronidase enzymes. Various biological sources are being explored to source hyaluronidase inhibitors. Polyphenols such as alkaloids, flavonoids and terpenes have demonstrated inhibition against HAases. In this study we have evaluated the HAase inhibition activity of date seed extract (SesZenNHA™) against the well established plant based HA inhibitor which comes from Senna seeds . The polysaccharide content, which is believed to be the phytochemical responsible for HA inhibitory activity of Date seeds, was found to be 18.73% glucose equivalents as against Seena Polysaccharides of 7%. In hyaluronidase inhibition activity,IC20 of date-seed extract was estimated to be 0.5mg/ml whereas IC20 of senna seed extracts was 2 mg/ml. Hence the proprietary ingredient derived from date seed holds 4 times better potential for HA inhibition. |
| Keywords: | Hyaluronan, hyaluronidase inhibitors, bioactive molecules, date seeds, Indian senna |
| Cite Article: | "Evaluation of Hyaluronidase activity of proprietary date seed extract (SesZenNHA™) for skin health applications", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 10, page no.446-451, October-2022, Available :http://www.ijnrd.org/papers/IJNRD2210053.pdf |
| Downloads: | 000118748 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2210053 Registration ID: 183339 Published In: Volume 7 Issue 10, October-2022 DOI (Digital Object Identifier): Page No: 446-451 Country: Mumbai, Maharashtra, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2210053 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2210053 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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