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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | FORMULATION AND EVALUATION OF FLOATING BILAYER TABLET OF METFORMIN HYDROCHLORIDE AND CHLORPROPAMIDE |
| Authors Name: | Mr. Ravi , Mr. Firoz Khan , Ms. Sana Sahil , Ms. Nida Khan , Dr. C.K. Tyagi |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_184991
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| Published Paper Id: | IJNRD2212158 |
| Published In: | Volume 7 Issue 12, December-2022 |
| DOI: | |
| Abstract: | The present investigation studied a novel bilayer tablet having an extended release system. There has been 70 years of research and development experience in the sustained drug release area since the patent, and a number of strategies have been developed to prolong drug level in the body. With many drugs, the basic goal of therapy is to achieve a steady-state blood or tissue level that therapeutically effective and non-toxic for an extended period of time. Floating Bilayer tablet of Metformin HCl as Instant Layer and Chlorpropamide as control layer were formulated using, HPMC, Sodium carboxymethyl cellulose, Microcrystalline cellulose, Sodium starch glycolate, Magnesium stearate in combination of different percentage of polymer. Nine different formulations of floating Chlorpropamide SR tablets are prepared by employing the hydrophilic polymer HPMC in different viscosity grades in the percentage. From this study it was concluded that Floating time increases, it decreases the release rate. So it suitable for sustained release formulation. The two agents were found to have a remarkable effect on glycemic control. In the present investigation a bilayer tablet was prepared in which one layer gives instant action against diabetes and another layer maintain concentration of drug in plasma for longer periods. |
| Keywords: | Diabetes, Chlorpropamide, Metformin HCL, Bilayer tablet |
| Cite Article: | "FORMULATION AND EVALUATION OF FLOATING BILAYER TABLET OF METFORMIN HYDROCHLORIDE AND CHLORPROPAMIDE", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 12, page no.b518-b529, December-2022, Available :http://www.ijnrd.org/papers/IJNRD2212158.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2212158 Registration ID: 184991 Published In: Volume 7 Issue 12, December-2022 DOI (Digital Object Identifier): Page No: b518-b529 Country: -, -, - Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2212158 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2212158 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
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