INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
In this paper, we present ultrasensitive silicon nanowire (SiNW)-based biosensor devices fordetection of disease biomarkers. The electrochemically induced functionalization method has was used to transplant antibodies targeted against a prostate cancer risk biomarker 8- of hydroxydeoxyguanosine (8-OHdG) onto SiNW surfaces. Antibody functionalized SiNWsensor was used to detect the binding of the biomarker 8-OHdG to the SiNW surface inside seconds of exposure. Detection of 8-OHdG concentrations as low as 1 ng/ml (3.5 nM) was proven. The active device has been connected to a disposable printed circuit board that can be inserted into the electronic reading system as part of an integrated Point of Care (POC) diagnostic. The speed, sensitivity, and ease of biomarker detection using SiNW sensors are depicted they are ideal for eventual POC diagnostics. A huge amount of research and development has been done in the field of nanotechnology and many nanomaterials have been used to detect cancer in its early stages. Nanomaterials have unique physical, optical and electrical properties that have been proven very useful for scanning. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon over the years, nanotubes, gold nanowires, and many other materials have been developed, along with the discovery of a wide range of biomarkers to lower the detection limit of cancer biomarkers. The basis is proteins, antibody fragments, DNA fragments and RNA fragments cancer biomarkers and have been used as targets in cancer detection and monitoring. It is highly anticipated that in the near future we might be able to detect cancer very early stage, providing a much higher chance of treatment.
"Modified Silicon Nanowire Biosensor:Synthesis Method and Early Cancer Diagnosis ", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 12, page no.b590-b604, December-2022, Available :http://www.ijnrd.org/papers/IJNRD2212170.pdf
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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