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IJNRD
INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
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Impact Factor : 8.76

Issue per Year : 12

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Published Paper Details
Paper Title: Modified Silicon Nanowire Biosensor:Synthesis Method and Early Cancer Diagnosis
Authors Name: Inamdar Farheen Muzammil , Kongale Aishwarya Bankat
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IJNRD_184565
Published Paper Id: IJNRD2212170
Published In: Volume 7 Issue 12, December-2022
DOI:
Abstract: In this paper, we present ultrasensitive silicon nanowire (SiNW)-based biosensor devices fordetection of disease biomarkers. The electrochemically induced functionalization method has was used to transplant antibodies targeted against a prostate cancer risk biomarker 8- of hydroxydeoxyguanosine (8-OHdG) onto SiNW surfaces. Antibody functionalized SiNWsensor was used to detect the binding of the biomarker 8-OHdG to the SiNW surface inside seconds of exposure. Detection of 8-OHdG concentrations as low as 1 ng/ml (3.5 nM) was proven. The active device has been connected to a disposable printed circuit board that can be inserted into the electronic reading system as part of an integrated Point of Care (POC) diagnostic. The speed, sensitivity, and ease of biomarker detection using SiNW sensors are depicted they are ideal for eventual POC diagnostics. A huge amount of research and development has been done in the field of nanotechnology and many nanomaterials have been used to detect cancer in its early stages. Nanomaterials have unique physical, optical and electrical properties that have been proven very useful for scanning. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon over the years, nanotubes, gold nanowires, and many other materials have been developed, along with the discovery of a wide range of biomarkers to lower the detection limit of cancer biomarkers. The basis is proteins, antibody fragments, DNA fragments and RNA fragments cancer biomarkers and have been used as targets in cancer detection and monitoring. It is highly anticipated that in the near future we might be able to detect cancer very early stage, providing a much higher chance of treatment.
Keywords: Silicon nanowire, Biosensor, Surface functionalization , Electron lithography, 8-hydroxydeoxyguanosine(8-OHdG), electronic readout, cancer biomarkers, gold nanoparticles, quantum dots, carbon nanotubes, nanowires, micro consoles
Cite Article: "Modified Silicon Nanowire Biosensor:Synthesis Method and Early Cancer Diagnosis ", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 12, page no.b590-b604, December-2022, Available :http://www.ijnrd.org/papers/IJNRD2212170.pdf
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ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID:IJNRD2212170
Registration ID: 184565
Published In: Volume 7 Issue 12, December-2022
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Page No: b590-b604
Country: Latur , Maharashtra , India
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2212170
Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2212170
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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