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IJNRD
INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
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Impact Factor : 8.76

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Paper Title: Method development and validation of pregabalin and duloxetine hydrochloride in bulk and pharmaceutical dosage form by UV and RP-HPLC using human plasma
Authors Name: R.N.Sathyaprakash , S.Ravichandran
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IJNRD_185889
Published Paper Id: IJNRD2301098
Published In: Volume 8 Issue 1, January-2023
DOI: http://doi.one/10.1729/Journal.32654
Abstract: This work is concerned with a new, simple, rapid, and precise UV and RP-HPLC method for determination of pregabalin and duloxetine hydrochloride in both bulk and in capsule. UV determination was carried out using Acetonitrile: water as solvent system. The maximum absorbance was observed at 267nm and 218nm for pregabalin and duloxetine hydrochloride respectively. Chromatographic separation was achieved isocratically using C18 column (250×4.6 mm, 5µm), mobile phase containing Acetonitrile and phosphate buffer (pH 6.8) in the ratio 40:60 maintained at flow rate 1 ml/min. Detection wavelength at 240nm. Retention time of pregabalin was found to be 1.8min and for duloxetine HCl 3.4 min. This method is then used for analysis of formulation. The developed method was validated in terms of ICH guidelines Q2(R1). The validation of proposed method was verified by recovery studies and was found to be satisfactory.
Keywords: UV, RP-HPLC, pregablin, duloxetine HCl, method development, validation.
Cite Article: "Method development and validation of pregabalin and duloxetine hydrochloride in bulk and pharmaceutical dosage form by UV and RP-HPLC using human plasma", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 1, page no.a871-a882, January-2023, Available :http://www.ijnrd.org/papers/IJNRD2301098.pdf
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ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID:IJNRD2301098
Registration ID: 185889
Published In: Volume 8 Issue 1, January-2023
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.32654
Page No: a871-a882
Country: Chengalpattu, Tamilnadu, India
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2301098
Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2301098
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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