INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
The sublingual route is very useful for quick onset of action and improved patient compliance. It improves drug utilization and the efficacy of active pharmaceutical ingredients. The oral route is the most preferred by patients. A fast dissolving oral drug delivery system is a solid dosage form that disintegrates or dissolves in the mouth in seconds without the use of water or chewing. The solubility and bioavailability of the drug were enhanced using solid dispersion. The solid dispersion of Benidipine hydrochloride: β-cyclodextrin was prepared in different ratios (1:1, 1:2, 1:3, 1:4) by physical mixture method. The current study discusses the formulation aspects, manufacturing methods such as solvent casting, evaluation parameters, and applications of fast dissolving films by the sublingual route made from polymers such as HPMC E-5, as a film forming agent Sodium starch glycolate, as a super disintegrating agent, Critic acid, as a saliva stimulating agent PEG 400 as a plasticizer and Mannitol as a sweetener. In this study was concluded that the fast dissolving sublingual film of Benidipine Hydrochloride showed a better result as compared to the marketed formulation and all the parameters showed acceptable results.
Keywords:
Hypertension, Sodium starch glycolate, ?-cyclodextrin, Sublingual film.
Cite Article:
"Formulation and Evaluation of Fast Dissolving Sublingual Film of Benidipine Hydrochloride for the Treatment of Hypertension", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 1, page no.d431-d440, January-2023, Available :http://www.ijnrd.org/papers/IJNRD2301351.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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