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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | A REVIEW: DRUG- EXCIPIENT INTERACTIONS STUDY |
| Authors Name: | Mr. Shiddesh D. Gawari , Ms.Sonali B. Jadhav , Dr. Hemant V. Kambale , Dr. Vivek M. Satpute , Santosh A. Waghmare |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_187576
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| Published Paper Id: | IJNRD2302162 |
| Published In: | Volume 8 Issue 2, February-2023 |
| DOI: | |
| Abstract: | Excipients are included in dosage forms to aid manufacture, administration or absorption. Although considered pharmacologically inert, excipients can initiate, propagate or participate in chemical or physical interactions with drug compounds, which may compromise the effectiveness of a medication. Exicipients are not exquisitely pure. Even for the most commonly used excipients, it is necessary to understand the context of their manufacture in order to identify potential active pharmaceutical ingredients interactions with trace components. Chemical interactions can lead to degradation of the active ingredient, thereby reducing the amount available for therapeutic effect. Physical interactions can affect rate of dissolution, uniformity of dose or ease of administration. Understanding the chemical and physical nature of excipients, the impurities or residues associated with them and how they may interact with other materials, or with each other, forewarns the pharmaceutical technologist of possibilities for undesirable developments. The potential physical and chemical interactions between drugs and excipients can affect the chemical, physical, therapeutical properties and stability of the dosage form. The present review contains a basic mode of drug degradation, mechanism of drug- excipient interaction like physical, chemical and biopharmaceutical. Different Thermal and Non-thermal method of analysis, Tools and software for incompatibility is also discussed. Once the type of interaction is determined we can take further steps to improve the stability of drug and dosage form. From review, we conclude that consequent use of thermal and non-thermal method provide data for drug- excipient interaction which can further help in selection of excipient for the development of stable dosage form. |
| Keywords: | Excipient, Drug, Interaction, Physical, Chemical |
| Cite Article: | "A REVIEW: DRUG- EXCIPIENT INTERACTIONS STUDY", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 2, page no.b641-b651, February-2023, Available :http://www.ijnrd.org/papers/IJNRD2302162.pdf |
| Downloads: | 000118763 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2302162 Registration ID: 187576 Published In: Volume 8 Issue 2, February-2023 DOI (Digital Object Identifier): Page No: b641-b651 Country: ahmednagar, maharashatra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2302162 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2302162 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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