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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | EVALUATION OF ANTIUROLITHIATIC ACTIVITY OF CAFFEIC ACID AGAINST ETHYLENE GLYCOLE-INDUCED RENAL CALCULI IN RATS |
| Authors Name: | Ms. Pooja Goswami , Ms. Meena Bharvadiya |
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IJNRD_187355
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| Published Paper Id: | IJNRD2302241 |
| Published In: | Volume 8 Issue 2, February-2023 |
| DOI: | |
| Abstract: | Objectives A sizable portion of the world's population suffers from kidney stones. For the prevention of new stone formation and relapse of existing stones, efficient measures must be developed. An organic compound called caffeic acid (CA), which is found in plants naturally, has a wide range of biological activity and is not hazardous to humans. Therefore, this study aims to evaluate the antiurolithiatic effect of CA in ethylene glycol-induced renal calculi in rats. Materials and methods To investigate the antiurolithiatic effects of CA, urolithiasis caused by ethylene glycol was produced (0.75% v/v). Eight groups of male Wistar rats—normal, diseased, preventive, and curative treatment groups—were created. Animals were slaughtered and their biochemical and histological characteristics were assessed at the conclusion of the treatment. Results The changed biochemical parameter was significantly controlled by CA treatment in the preventive and curative groups, and calcium oxalate deposits in the kidneys were noticeably reduced. Treatment with CA at doses of 50 and 100 mg/kg significantly (P 0.001) reduced serum toxicity markers (such as blood urea nitrogen, uric acid, urea, and creatinine), antioxidant machinery, minerals (such as Ca, Mg, P, and oxalate), and urinary markers (i.e. urine pH and urine output). Conclusions The current study provides definite evidence that CA can be used to treat urolithiasis and prevent further development of the condition. Keywords Urolithiasis, Hyperoxaluria, Ethylene Glycol, Diuretic, Caffeic acid. |
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| Cite Article: | "EVALUATION OF ANTIUROLITHIATIC ACTIVITY OF CAFFEIC ACID AGAINST ETHYLENE GLYCOLE-INDUCED RENAL CALCULI IN RATS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 2, page no.c363-c369, February-2023, Available :http://www.ijnrd.org/papers/IJNRD2302241.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2302241 Registration ID: 187355 Published In: Volume 8 Issue 2, February-2023 DOI (Digital Object Identifier): Page No: c363-c369 Country: Vadodara, Gujrat, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2302241 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2302241 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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