INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
The present study was undertaken to synthesized phenytoin using benzil and urea by using microwave synthesizer and solid dispersion of phenytoin was prepared using with different carriers such as PEG -6000, PVPK-30 and D – Mannitol bythe solvent evaporation method for increasing dissolution rate and bioavailability of the drug. Polymers used in solid dispersion techniques are hydrophilic in nature and compatible with drug to enhance drug dissolution rate. These different ratios of solid dispersion were characterized by UV spectroscopy for saturated solubility and dissolution study and it was observed that and dissolution rate was enhanced in the ratio of PEG -6000 (1:3) as compared to other ratios of other carriers
Keywords:
solid dispersion, poorly water soluble, hydrophilic polymers
Cite Article:
"“SYNTHESIS AND SOLUBILITY ENHANCEMENT OF PHENYTOIN BY SOLID DISPERSION USING VARIOUS POLYMERS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 2, page no.c513-c522, February-2023, Available :http://www.ijnrd.org/papers/IJNRD2302261.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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