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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Formulation and Evaluation Osmoregulated drug delivery system of Salbutamol Sulphate |
| Authors Name: | Ms Karishma Sharma |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_187911
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| Published Paper Id: | IJNRD2302262 |
| Published In: | Volume 8 Issue 2, February-2023 |
| DOI: | |
| Abstract: | The present study was undertaken to design, fabricate and evaluate the controlled porosity osmotic pump tablet (CPOP) of sympathomimetic drug salbutamol sulphate to prolong the drug release, minimize early morning and nocturnal asthamatic attacks, and better patient compliance. The core tablets were prepared by wet granulation method and coated with cellulose acetate as semipermeable membrane to control the drug release. The flow properties of designed core formulations were also studied. The prepared CPOP tablets were evaluated for weight variation, thickness, hardness and drug release. The estimated parameters were found within range. The developed CPOP tablets of salbutamol sulphate exhibited drug release for 12 hrs. Moreover, the drug release of optimized batch was compared with marketed formulation and the result indicates similar drug release profile. The drug release was found dependant on osmogen concentration and increased with rise in concentration of osmogen. Hence, CPOP tablets of salbutamol sulphate, coated with widely employed semipermeable membrane cellulose acetate with prolonged drug release for 12 hr and independent of GI conditions were successfully prepared and evaluated. |
| Keywords: | Osmosis, controlled release, semipermeable membrane, salbutamol sulphate, drug release |
| Cite Article: | "Formulation and Evaluation Osmoregulated drug delivery system of Salbutamol Sulphate", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 2, page no.c523-c540, February-2023, Available :http://www.ijnrd.org/papers/IJNRD2302262.pdf |
| Downloads: | 000118750 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2302262 Registration ID: 187911 Published In: Volume 8 Issue 2, February-2023 DOI (Digital Object Identifier): Page No: c523-c540 Country: Hyderabad, Telagana, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2302262 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2302262 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
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