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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | FORMULATION AND EVALUATION OF FLOATING MICROBALLOONS OF ALLOPURINOL |
| Authors Name: | Prachi Gohil |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_187938
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| Published Paper Id: | IJNRD2302273 |
| Published In: | Volume 8 Issue 2, February-2023 |
| DOI: | |
| Abstract: | To formulate physically and chemically sustained release formulation of allopurinol by using a gastro retentive drug delivery system with the floating approach. Sustained release floating microballoons containing allopurinol was formulated by solvent evaporation method with sustained release polymer, DCM and ethanol as organic solvents and tween 80 as a processing medium by using 32 factorial designs. The independent factors were concentration of Eudragit RS 100 and tween 80 whereas dependent factors were % entrapment efficiency and % drug release. The prepared batches were evaluated for particle size, % entrapment efficiency, drug loading, floating time, total floating time and in-vitro drug release. During experiment the concentration of polymer increases shows decrease in entrapment, drug release and also affect the floating property. Thus, in moderate concentration of polymer shows excellent result of % entrapment efficiency, % drug release, floating property and sustained drug delivery. Evaluations were performed for optimized batch (B3) shows 1.04 seconds floating time, 97.45% drug entrapment efficiency, 98.19% drug release at 12 hours and total floating time up to 12hours. The sustained release floating microballoons system is a promising novel drug delivery system for the treatment of gout using allopurinol as a drug. This system is used because it enhances the floating behavior at upper part of GIT as microballoons have low density and hollow space, also the drug has solubility on upperpart of GIT |
| Keywords: | Floating, microparticulate, hollow sphere, allopurinol |
| Cite Article: | "FORMULATION AND EVALUATION OF FLOATING MICROBALLOONS OF ALLOPURINOL", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 2, page no.c657-c665, February-2023, Available :http://www.ijnrd.org/papers/IJNRD2302273.pdf |
| Downloads: | 000118754 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2302273 Registration ID: 187938 Published In: Volume 8 Issue 2, February-2023 DOI (Digital Object Identifier): Page No: c657-c665 Country: Vadodara, Gujarat, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2302273 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2302273 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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