Assessment and management of ADR associated with cancer chemotherapy in a tertiary care hospital

Registration ID: IJNRD_193875

Published ID: IJNRD2305055

: http://doi.one/10.1729/Journal.34089

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Kadeejath Thashrifa Shereen B , Risvana Abdul Rahiman P, Karthik MM, Shama Banu KP, Dr. Suja C

Adverse drug reaction, causality, chemotherapy, pharmacovigilance.

Aim: The objective of the study was to assess the causality, severity and preventability of ADRs detected by chemotherapeutic medications and to assess their management. Methodology: A prospective observational study was conducted for 6 months among 108 patients. Results: The study found a total of 263 ADRs, with the gastrointestinal system being the most affected organ system (28.6%).The drug Paclitaxel caused the highest number of ADRs when administered as monotherapy, while paclitaxel+carboplatin caused the highest number of ADRs when taken in combination. Causality was assessed using Naranjo’s causality assessment scale, it was found that 87.1% of the ADRs were probable, 7.6% were possible, and 5.3% were definite. The severity of ADRs was assessed using the Hartwig & Siegal scale, and the study found that 49.8% of ADRs were moderate level 3, 34.6% were moderate level 4a, 10.3% were mild level 2, 4.2% were moderate level 4b, and 1.1% were mild level 1.The preventability of the ADRs was assessed using the Modified Schumock and Thornton preventability scale, it was found that 68.4% of ADRs were not preventable, 18.6% were probably preventable, and 12.9% were definitely preventable. The study also found that the ADRs were managed by providing additional treatment without changing the drug regimen. Conclusion : ADRs are the major concern in patient safety and are responsible for a significant amount of mortality and morbidity, as well as financial burden on patients. It is essential to keep ADR in track, and early detection/ monitoring could help reduce the risk of one’s health.

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Kadeejath Thashrifa Shereen B , Risvana Abdul Rahiman P, Karthik MM, Shama Banu KP, & Dr. Suja C (May-2023). Assessment and management of ADR associated with cancer chemotherapy in a tertiary care hospital . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(5), a422-a447. http://doi.one/10.1729/Journal.34089

Volume 8 Issue 5, May-2023

Pages : a422-a447

Paper Reg. ID: IJNRD_193875

Published Paper Id: IJNRD2305055

Research Area: Pharmacy

Author Type: Indian Author

Country: Kasaragod, Kerala, India

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Crossref DOI: http://doi.one/10.1729/Journal.34089

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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