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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Assessment and management of ADR associated with cancer chemotherapy in a tertiary care hospital |
| Authors Name: | Kadeejath Thashrifa Shereen B , Risvana Abdul Rahiman P , Karthik MM , Shama Banu KP , Dr. Suja C |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_193875
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| Published Paper Id: | IJNRD2305055 |
| Published In: | Volume 8 Issue 5, May-2023 |
| DOI: | http://doi.one/10.1729/Journal.34089 |
| Abstract: | Aim: The objective of the study was to assess the causality, severity and preventability of ADRs detected by chemotherapeutic medications and to assess their management. Methodology: A prospective observational study was conducted for 6 months among 108 patients. Results: The study found a total of 263 ADRs, with the gastrointestinal system being the most affected organ system (28.6%).The drug Paclitaxel caused the highest number of ADRs when administered as monotherapy, while paclitaxel+carboplatin caused the highest number of ADRs when taken in combination. Causality was assessed using Naranjo’s causality assessment scale, it was found that 87.1% of the ADRs were probable, 7.6% were possible, and 5.3% were definite. The severity of ADRs was assessed using the Hartwig & Siegal scale, and the study found that 49.8% of ADRs were moderate level 3, 34.6% were moderate level 4a, 10.3% were mild level 2, 4.2% were moderate level 4b, and 1.1% were mild level 1.The preventability of the ADRs was assessed using the Modified Schumock and Thornton preventability scale, it was found that 68.4% of ADRs were not preventable, 18.6% were probably preventable, and 12.9% were definitely preventable. The study also found that the ADRs were managed by providing additional treatment without changing the drug regimen. Conclusion : ADRs are the major concern in patient safety and are responsible for a significant amount of mortality and morbidity, as well as financial burden on patients. It is essential to keep ADR in track, and early detection/ monitoring could help reduce the risk of one’s health. |
| Keywords: | Adverse drug reaction, causality, chemotherapy, pharmacovigilance. |
| Cite Article: | "Assessment and management of ADR associated with cancer chemotherapy in a tertiary care hospital ", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.a422-a447, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305055.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2305055 Registration ID: 193875 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.34089 Page No: a422-a447 Country: Kasaragod, Kerala, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2305055 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2305055 |
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ISSN: 2456-4184
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