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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Design, characterization and Evaluation of mouth dissolving film (MDF) containing Enalapril maleate. |
| Authors Name: | Taral Mayur Navnath , Kashid Vivekanand Ankush |
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| Author Reg. ID: |
IJNRD_195932
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| Published Paper Id: | IJNRD2305488 |
| Published In: | Volume 8 Issue 5, May-2023 |
| DOI: | |
| Abstract: | Many pediatric and geriatric patients are unwilling to take solid preparations due to fear of choking. To avoid such difficulties, film like dosage forms were developed. The aim of this study was to formulate and optimized mouth dissolving film containing Enalapril maleate by 3 level 2 factor full factorial design using design expert® software. Mouth dissolving film was formulated by using solvent casting method. HPMC E15 and sodium starch glycolate concentrations were selected as independent variable. Enalapril maleate containing film of HPMC E15 was optimized by selecting the disintegration time and tensile strength as response which is evaluated by design expert® software. Disintegration time is important constraint for immediate release dosage form. Concentrations of HPMC E15 and sodium starch glycolate affect the disintegration of film and tensile strength. Desirability for Quadratic model was significant compare to other models. About 99.77 % of drug release was obtained from In vitro drug release study and follows korsmeyer peppas model. Films were characterized by using DSC Thickness, tensile strength, folding endurance test and evaluated for their physical and mechanical properties. Stability study of optimized film for two months reveals that formulation was stable for specified time period. From this study it was concluded that disintegration time was directly proportional to concentration of sodium starch glycolate and inversely proportional to concentration of HPMC E15.Concentration of Sodium starch glycolate directly proportional to tensile strength and inversely proportional to disintegration time. |
| Keywords: | dissolving, release, film, HPMC, disintegration |
| Cite Article: | "Design, characterization and Evaluation of mouth dissolving film (MDF) containing Enalapril maleate.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.e717-e730, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305488.pdf |
| Downloads: | 000118754 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2305488 Registration ID: 195932 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: e717-e730 Country: Ahmednagar, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2305488 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2305488 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
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