INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
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Published Paper Details
Paper Title:
DEVELOPMENT AND VALIDATION OF LCMS/MS METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN & EMPAGLIFLOZIN IN TABLET AND CHARACTERI-ZATION OF DEGRADANT BY LC-MS/MS
Authors Name:
Ashok kumar Chaudhari
, Mr. Rakesh Patel , Ms. Vanita Marvaniya , Dr. Chaitanya Bhatt
A simple, rapid, precise and accurate Stability indicating LC-MS/MS method for simulta-neous estimation of Metformin and Empagliflozin in their combined dosage form has been developed. The separation was achieved by Agilent, Zorbax, C18, (150mm x 4.6mm), 5µm column and Buffer (Ammonium acetate): Acetonitrile (75:25) as mobile phase, at a flow rate of 1 ml/min. Detection was carried out. Retention time of Empagliflozin and Metfor-min were found to be 2.6 min and 5.16 min respectively. The method has been validated for linearity, accuracy and precision. Linearity observed for Metformin 5μg/ml and for Em-pagliflozin 1.25 μg/ml. Developed method was found to be accurate, precise and rapid for simultaneous estimation of Metformin and Empagliflozin their Combined Dosage Form. The drug was subjected to stress condition of hydrolysis, oxidation, photolysis and Thermal degradation, Considerable Degradation was found in Alkali and Oxidation degradation. The proposed method was successfully applied for the simultaneous estimation of both the drugs in commercial combined dosage form.
"DEVELOPMENT AND VALIDATION OF LCMS/MS METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN & EMPAGLIFLOZIN IN TABLET AND CHARACTERI-ZATION OF DEGRADANT BY LC-MS/MS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.i440-i456, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305856.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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