INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
The present study was focused to develop a simple, precise, accurate and cost effective HPLC method for estimation of Nilotinib from pharmaceutical dosage form. The chromatographic method was carried out using Younglin (S.K) Gradient System UV Detector, Detecter & pump No.UV 730 D & SP930 D,Autochro -3000 software,Column 4.6 x 250 mm, C-18 {4.6 x 250 mm (5µm)}Particle size packing 5 m,Stationary phase C18 ,C-18 {4.6 x 250 mm (5µm)},Mobile phase Methanol (80) : Water(20) (0.1 % Acetic Acid ).The flow rate was set 0.8 ml/min with 20 l injection volume. Total run time was 4.71min Detection was carried out at wavelength of 260nm.The detector response was linear in the range of 5-25μg/ml .The % recoveries obtained in the accuracy study were 98.28-101.58% .The LOD was found to be 0.1198g/ml.The LOQ was found to be 0.3631g/ml
The developed method is successfully applied for estimation of Nilotinib from pharmaceutical dosage form.
"Analytical Method Development And Validation For Determination Of Nilotinib By HPLC", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.i464-i484, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305858.pdf
Downloads:
000118753
ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Facebook Twitter Instagram LinkedIn