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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Warfarin And Its Interactions With Statins And Amiodarone |
| Authors Name: | Arshiya Jahan , Mohammed Junaid Javed , Nishath , Dr.A.V Kishore babu , Dr.A.Srinivasa Rao |
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IJNRD_205620
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| Published Paper Id: | IJNRD2309244 |
| Published In: | Volume 8 Issue 9, September-2023 |
| DOI: | |
| Abstract: | This is a comparative review which highlights the interactions of warfarin with statins and amiodarone. Warfarin is used in patients with thromboembolism and is commonly prescribed oral anticoagulant which is a vitamin-k antagonist. Drugs like statins and amiodarone are prescribed for atrial fibrillation and myocardial ischemia simultaneously with warfarin leading to potential drug interaction. Even though these drugs are frequently prescribed with warfarin clinical guidelines on these drug combinations are divergent. Warfarin is highly effective and safe but both efficacy and safety depend upon blood international normalized ratio. Monitoring INR and dose adjustment can be beneficial for effective warfarin therapy. Warfarin, statins and amiodarone are metabolized by Cyt-p450 enzymes leading to possible interactions. Warfarin, when co-administered with statins, inhibits the metabolic pathway of statins causing increased pharmacological action of statins leading to increased risk of drug toxicity and rhabdomyolysis whereas when warfarin is co-administered with Amiodarone, amiodarone inhibits the metabolic pathway of warfarin causing increased anticoagulant effect. The metabolic pathway of warfarin not only interacts with cardiovascular agents but also many dietary supplements making it necessary to monitor the therapy. The main goal of anticoagulation therapy with warfarin should be to administer least effective dose possible that obtains the required International normalized ratio. The initiation of warfarin can be more challenging due to its narrow therapeutic index and pharmacodynamic response is highly unpredictable due to varied individual susceptibility. |
| Keywords: | Warfarin, Amiodarone, Statins, INR, CYP2C9 |
| Cite Article: | "Warfarin And Its Interactions With Statins And Amiodarone", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 9, page no.c388-c391, September-2023, Available :http://www.ijnrd.org/papers/IJNRD2309244.pdf |
| Downloads: | 000118753 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2309244 Registration ID: 205620 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: c388-c391 Country: Hyderabad, Telangana, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2309244 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2309244 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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