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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | LINACLOTIDE: A NEW CURE FOR PEDIATRIC FUNCTIONAL CONSTIPATION |
| Authors Name: | Dr.Dhivya R , Dr. Velvizhy R , Dr.Priyadharsini P , Dr.Kawsalliya Raj k |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_205400
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| Published Paper Id: | IJNRD2310004 |
| Published In: | Volume 8 Issue 10, October-2023 |
| DOI: | http://doi.one/10.1729/Journal.36366 |
| Abstract: | Linaclotide, a secretory agent acting on Guanylyl cyclase C in the intestinal epithelium is approved for pediatric functional constipation in the age group between 6 years and 17 years by FDA in June 2023. Linaclotide is similar in structure to human guanylin and uroguanylin which acts as an agonist for Guanylyl cyclase C (GC-C)1. It was previously approved for treating constipation-predominant Irritable bowel syndrome and chronic idiopathic constipation in adults. Functional constipation is idiopathic constipation that occurs most commonly in children at school entry age with a history of ≤2 defecations in the toilet per week or ≥1 episode of faecal incontinence per week2. So far the management included stool softeners, enema, laxatives or behavioral management in functional constipation. Recently FDA approved an oral pharmacological agent LINACLOTIDE for functional constipation in children between 6 years and 17 years. This review will briefly summarize the pharmacological properties and the use of Linaclotide in pediatric functional constipation. |
| Keywords: | Functional constipation, Linaclotide, Guanylyl Cyclase-C |
| Cite Article: | "LINACLOTIDE: A NEW CURE FOR PEDIATRIC FUNCTIONAL CONSTIPATION", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 10, page no.a25-a26, October-2023, Available :http://www.ijnrd.org/papers/IJNRD2310004.pdf |
| Downloads: | 000118763 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2310004 Registration ID: 205400 Published In: Volume 8 Issue 10, October-2023 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.36366 Page No: a25-a26 Country: KARAIKAL, pondicherry, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2310004 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2310004 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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