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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Synthesis and Characterization of Potential Impurities in Imatinib Mesylate |
| Authors Name: | Dr. Pramila.T , Poojashree |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_207056
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| Published Paper Id: | IJNRD2310214 |
| Published In: | Volume 8 Issue 10, October-2023 |
| DOI: | |
| Abstract: | Imatinib mesylate is a potent antineoplastic agent that acts as a tyrosine kinase inhibitor (TK inhibitor). Specifically, it is used for the treatment of different types of cancers such as chronic Myelogenous leukemia (CML), acute lymphocytic leukemia (ALL), Philadelphia chromosome-positive (ph+), certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES). Genotoxicity describes the property of chemical agents that damage the genetic information or DNA within a cell causing mutations, which may lead to cancer, Impurities which will cause the mutation are known as genotoxic impurities. During the process of Imatinib mesylate synthesis, the formation of various Imatinib impurities was observed, which may or may not act as genotoxic on cells or DNA and will cause mutation which was not reported earlier. Although, the structures and analytical procedures of these impurities have been already reported in the literature, surprisingly their synthesis and genotoxic evaluation were not accounted for. In the present investigation, the synthesis of Imatinib impurity A, B, C, F and J were achieved by designing a new and simple method, the synthesized compounds were characterized and confirmed by using IR, 1H-NMR and Mass Spectrometry for evaluation of genotoxic nature of imatinib impurities. |
| Keywords: | Characterization, Imatinib mesylate, Imatinib impurities, Synthesis |
| Cite Article: | "Synthesis and Characterization of Potential Impurities in Imatinib Mesylate", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 10, page no.c133-c141, October-2023, Available :http://www.ijnrd.org/papers/IJNRD2310214.pdf |
| Downloads: | 000118760 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2310214 Registration ID: 207056 Published In: Volume 8 Issue 10, October-2023 DOI (Digital Object Identifier): Page No: c133-c141 Country: MANDYA, KARNATAKA, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2310214 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2310214 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
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