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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Immune Cells in Fracture Healing |
| Authors Name: | Dharmendra Kumar , Ankit Sriwastava , Anand Kumar , Rahul Kirti Sharma , Vivek Kumar |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_206777
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| Published Paper Id: | IJNRD2310236 |
| Published In: | Volume 8 Issue 10, October-2023 |
| DOI: | http://doi.one/10.1729/Journal.36614 |
| Abstract: | Abstract: Fracture healing is a complex and dynamic biological process essential for the restoration of bone structure and function following injury. This paper delves into the intricate roles of immune cells throughout the stages of fracture healing, encompassing the inflammatory, proliferative, and remodeling phases. The immune system, comprising both innate and adaptive components, orchestrates the response to fractures, with immune cells like neutrophils, macrophages, T lymphocytes, and monocytes actively contributing to tissue repair and regeneration. In the inflammatory phase, neutrophils serve as the vanguard, swiftly clearing debris and pathogens, while macrophages coordinate the resolution of inflammation and release essential growth factors. Mast cells, though lesser known, also participate in this early response. During the proliferative phase, T lymphocytes and monocytes play vital roles in angiogenesis, fibroblast activation, and osteoblast function, all of which are crucial for successful healing. The final stage, the remodeling phase, witnesses a transition in immune cell activity from pro-inflammatory to anti-inflammatory. Macrophages, in particular, assist in resolving inflammation. Moreover, immune cells regulate osteoclast activity and bone remodeling, ensuring the restoration of bone strength. Immune cells also engage with mesenchymal stem cells, further influencing the tissue regeneration process. This research holds promising implications for understanding non-union and delayed fracture healing, as well as for the development of targeted therapeutic strategies to enhance patient outcomes. However, the complexities of immune cell interactions require further investigation to translate these findings into clinical applications. Ultimately, this paper underscores the pivotal role of immune cells in fracture healing, offering a comprehensive understanding of the subject and its potential for advancing patient care and innovative therapies. |
| Keywords: | Fracture healing, Immune cells, Bone regeneration, Non-union |
| Cite Article: | "Immune Cells in Fracture Healing", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 10, page no.c312-c316, October-2023, Available :http://www.ijnrd.org/papers/IJNRD2310236.pdf |
| Downloads: | 000118760 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2310236 Registration ID: 206777 Published In: Volume 8 Issue 10, October-2023 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.36614 Page No: c312-c316 Country: Lucknow, Uttar Pradesh, India Research Area: Life Sciences Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2310236 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2310236 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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