Novel Approaches for colon targeting drug delivery system.

Novel Approaches for colon targeting drug delivery system.

Registration ID: IJNRD_210709

Published ID: IJNRD2312137

DOI: Click Here to Get

Damayanti Krishna Bokefod , Ms. Khandre Rajshree

Colon drug delivery system, Gastro intestinal tract, Approaches for CDDS,

The GIT terminal part known as colon, has emerged as potential site for delivering various novel therapeutic drugs, particularly peptides. Colon targeted drug delivery system (CDDS) shows promise in treating inflammatory bowel diseases such as ulcerative colitis, Crohn’s disuse, colon cancer, and amoebiasis through both systemic and topical drug delivery. This article provides comprehensive review of colon diseases, their diagnosis, the anatomy of the colon, factors influencing drug absorption, and different approaches to colon drug delivery. It also discusses current approaches like the port system, probiotic approach, chronotropic system, colal-pred system, Enterion capsule Technology Multiarticulate system, as well as past studies on colon drug delivery, including evaluation method for site-specific drug delivery to colon. Numerous traditional methods, such as PH-dependent systems, time-controlled release systems, and microbially triggered systems, have been extensively studied for targeted drug delivery to the colon. However, these systems possess their own drawbacks, such as the inconsistent PH conditions in the colon, insufficient specificity for microbial enzymes, and limited capacity for drug loading. To overcome these limitations, novel approaches like nanotechnology-based drug delivery systems, prodrug approaches, and bioadhesive systems have been developed.

Published Paper   E-Certificate

"Novel Approaches for colon targeting drug delivery system.", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 12, page no.b179-b196, December-2023, Available :https://ijnrd.org/papers/IJNRD2312137.pdf

Volume 8 Issue 12, December-2023

Pages : b179-b196

Paper Reg. ID: IJNRD_210709

Published Paper Id: IJNRD2312137

Downloads: 000121131

Research Area: Pharmacy

Country: Ahmednagar, Maharashtra , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2312137.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2312137

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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