INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
In cancer treatment, efficient drug delivery systems are imperative to enhance therapeutic efficacy while minimizing systemic toxicity. This study explores the potential of a novel nano-complex composed of PAMAM G4 dendrimers and vitamin D for the targeted delivery of doxorubicin (DOX), a widely used chemotherapeutic agent. The synthesis and characterization of the nano-complex were meticulously conducted, elucidating its physicochemical properties and structural integrity.The encapsulation of DOX within the nano-complex was optimized, ensuring high drug loading efficiency and sustained release kinetics. Moreover, the synergistic effects of vitamin D were harnessed to augment the anticancer activity of DOX while mitigating its adverse effects on normal tissues. Cellular uptake studies revealed enhanced internalization of the nano-complex in cancer cells, facilitated by receptor-mediated endocytosis mechanisms.In vitro studies demonstrated the superior cytotoxicity of the DOX-loaded nano-complex compared to free DOX, attributed to its targeted delivery and intracellular release. Furthermore, the nano-complex exhibited favorable biocompatibility profiles, minimizing off-target effects on healthy cells. In vivo efficacy assessments using xenograft tumor models corroborated the enhanced therapeutic outcomes of the nano-complex, showcasing significant tumor growth inhibition and prolonged survival rates compared to conventional DOX formulations. Pharmacokinetic studies indicated improved circulation half-life and bioavailability of DOX when delivered via the nano-complex.
Keywords:
Dendrimer, Doxorubicin, Vitamin D, Cancer therapy, Drug release kinetics, Targeted delivery, In vivo efficacy.
Cite Article:
"PAMAM G4 Dendrimers & Vitamin D Nano Complex for delivery of Doxorubicin", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 3, page no.d102-d113, March-2024, Available :http://www.ijnrd.org/papers/IJNRD2403315.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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