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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | PAMAM G4 Dendrimers & Vitamin D Nano Complex for delivery of Doxorubicin |
| Authors Name: | Pragati Singh , Nancy Tiwari , Ranveer Singh , Priyanka Singh |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_215840
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| Published Paper Id: | IJNRD2403315 |
| Published In: | Volume 9 Issue 3, March-2024 |
| DOI: | http://doi.one/10.1729/Journal.38481 |
| Abstract: | In cancer treatment, efficient drug delivery systems are imperative to enhance therapeutic efficacy while minimizing systemic toxicity. This study explores the potential of a novel nano-complex composed of PAMAM G4 dendrimers and vitamin D for the targeted delivery of doxorubicin (DOX), a widely used chemotherapeutic agent. The synthesis and characterization of the nano-complex were meticulously conducted, elucidating its physicochemical properties and structural integrity.The encapsulation of DOX within the nano-complex was optimized, ensuring high drug loading efficiency and sustained release kinetics. Moreover, the synergistic effects of vitamin D were harnessed to augment the anticancer activity of DOX while mitigating its adverse effects on normal tissues. Cellular uptake studies revealed enhanced internalization of the nano-complex in cancer cells, facilitated by receptor-mediated endocytosis mechanisms.In vitro studies demonstrated the superior cytotoxicity of the DOX-loaded nano-complex compared to free DOX, attributed to its targeted delivery and intracellular release. Furthermore, the nano-complex exhibited favorable biocompatibility profiles, minimizing off-target effects on healthy cells. In vivo efficacy assessments using xenograft tumor models corroborated the enhanced therapeutic outcomes of the nano-complex, showcasing significant tumor growth inhibition and prolonged survival rates compared to conventional DOX formulations. Pharmacokinetic studies indicated improved circulation half-life and bioavailability of DOX when delivered via the nano-complex. |
| Keywords: | Dendrimer, Doxorubicin, Vitamin D, Cancer therapy, Drug release kinetics, Targeted delivery, In vivo efficacy. |
| Cite Article: | "PAMAM G4 Dendrimers & Vitamin D Nano Complex for delivery of Doxorubicin", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 3, page no.d102-d113, March-2024, Available :http://www.ijnrd.org/papers/IJNRD2403315.pdf |
| Downloads: | 00057 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2403315 Registration ID: 215840 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.38481 Page No: d102-d113 Country: Lucknow, Uttar Pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2403315 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2403315 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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