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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Design , Synthesis and Biological Evaluation of 1,2,4-triazole as an Antimicrobial agent. |
| Authors Name: | Sachi Dixit , Dr. Parulben Mehta , Dr. Shivakant Shukla |
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| Author Reg. ID: |
IJNRD_184141
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| Published Paper Id: | IJNRD2211156 |
| Published In: | Volume 7 Issue 11, November-2022 |
| DOI: | |
| Abstract: | New compounds were synthesized containing 1,2,4-triazole derivatives and tested for their antibacterial activity against gram positive and gram positive strains. A series of N-(3-(4-fluorophenyl)-5-mercaptp-4H-1,2,4-triazole-4-yl)-2-(substituted amines)acetamide were synthesized by esterification of 4- fluorobenzoic acid and further cyclization of hydrazide which is followed by reaction of carbon – di -sulfide and potassium hydrozide with the formation of intermediate potassium salt. The triazole prepared was subjected to N-acetylation with the treatment of choro acetyl chloride and formed the acetamide. The obtained nucleus was subjected to form different substituted derivatives with the treatment of 5 different secondary amines. The compounds were synthesized by conventional method and the stuctures of newly synthesized compounds were characterized by performing various physical as spectral techniques. This involves TLC, M.P , UV spectroscopy , FTIR and NMR spectroscopy . the antibacterial assay was performed for all the synthesized compounds by well diffusion method. The antibacterial screening reveals that the compound N-(3-(4-fluoro[phenyl)-5-mercapto-4H-1,2,4-triazole-4-yl)-2-((4-fluorophenyl)amino)acetamide (SA-03) was showed more promised and significant zone of incubation against Bacillus Subtilis and Pseudomonas aeruginosa ad show moderate activity as that of Standard Ofloxacin and Gentamycin against gram positive ad gram negative bacteria . |
| Keywords: | 1,2,4-Triazole , Hydrazine hydrate , antimicrobial agent , antibacterial activity. |
| Cite Article: | "Design , Synthesis and Biological Evaluation of 1,2,4-triazole as an Antimicrobial agent.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 11, page no.b492-b499, November-2022, Available :http://www.ijnrd.org/papers/IJNRD2211156.pdf |
| Downloads: | 000118749 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2211156 Registration ID: 184141 Published In: Volume 7 Issue 11, November-2022 DOI (Digital Object Identifier): Page No: b492-b499 Country: Bhopal, Madhya Pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2211156 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2211156 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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