Paper Title
Formulation and Evaluation of Nanoparticles of an Antianginal Drug for Transdermal Delivery
Article Identifiers
: Authors
Keywords
Nanoparticles; Nifedipine; Compritol 888 ATO; Span 60; Tween 80; Optimization etc...
Abstract
Solid Lipid Nanoparticles of Nifedipine were prepared by using Solvent emulsification evaporation method by using Compritol 888 ATO as Lipid, Span 60 and Tween 80 as Surfactants. The optimization was carried out using design expert software. The Central composite design (CCD) was selected to study the influence of critical formulation parameters. The prepared nanoparticles were evaluated for particle size, poly dispersity index, zeta potential, entrapment efficiency, drug content and In-vitro drug release studies using statistical methods. The particle size and entrapment efficiency of the nanoparticles was found to increase with increase in Compritol concentration and decrease in particle size with increasing tween 80. The optimized concentration for independent variables Compritol 888 ATO (X1) and Span 60/Tween 80 (X2) was found to be 2gm and 2gm respectively, with a desirability of 0.842 by Numerical optimization method. This was found to be in close agreement with the experimental response of formulation F1. It was concluded that the solid lipid nanoparticles of Nifedipine can be successfully formulated by solvent emulsification evaporation method.
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How To Cite (APA)
Pavitra malipatil, Dr.Rama bukka, & Praveen s (March-2023). Formulation and Evaluation of Nanoparticles of an Antianginal Drug for Transdermal Delivery. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(3), c695-c705. https://ijnrd.org/papers/IJNRD2303278.pdf
Issue
Volume 8 Issue 3, March-2023
Pages : c695-c705
Other Publication Details
Paper Reg. ID: IJNRD_188878
Published Paper Id: IJNRD2303278
Downloads: 000122253
Research Area: Pharmacy
Author Type: Indian Author
Country: Bangalore, Karnataka, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2303278.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303278
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