Formulation and Evaluation of Nanoparticles of an Antianginal Drug for Transdermal Delivery

Pavitra malipatil , Dr.Rama bukka , Praveen s

Nanoparticles; Nifedipine; Compritol 888 ATO; Span 60; Tween 80; Optimization etc...

Solid Lipid Nanoparticles of Nifedipine were prepared by using Solvent emulsification evaporation method by using Compritol 888 ATO as Lipid, Span 60 and Tween 80 as Surfactants. The optimization was carried out using design expert software. The Central composite design (CCD) was selected to study the influence of critical formulation parameters. The prepared nanoparticles were evaluated for particle size, poly dispersity index, zeta potential, entrapment efficiency, drug content and In-vitro drug release studies using statistical methods. The particle size and entrapment efficiency of the nanoparticles was found to increase with increase in Compritol concentration and decrease in particle size with increasing tween 80. The optimized concentration for independent variables Compritol 888 ATO (X1) and Span 60/Tween 80 (X2) was found to be 2gm and 2gm respectively, with a desirability of 0.842 by Numerical optimization method. This was found to be in close agreement with the experimental response of formulation F1. It was concluded that the solid lipid nanoparticles of Nifedipine can be successfully formulated by solvent emulsification evaporation method.

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"Formulation and Evaluation of Nanoparticles of an Antianginal Drug for Transdermal Delivery", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 3, page no.c695-c705, March-2023, Available :https://ijnrd.org/papers/IJNRD2303278.pdf

Volume 8 Issue 3, March-2023

Pages : c695-c705

Paper Reg. ID: IJNRD_188878

Published Paper Id: IJNRD2303278

Downloads: 000118870

Research Area: Pharmacy

Country: Bangalore, Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2303278

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303278

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

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