PHARMACOLOGICAL EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF FRUITS EXTRACT OF SYZYGIUM AEORANTHUM

Registration ID: IJNRD_190653

Published ID: IJNRD2304138

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Deepak kumar, Mr. Dhyanendra Singh, Mrs. Pranali Mishra, Dr.Vishal Gupta

Syzygium aeoranthum fruits, Hepatotoxicity, phytochemicals

Hepatotoxicity is a major side effect of synthetic drugs. It has important causes for the withdrawal and banning of most of drugs in the Pharmaceutical market. It is also a significant contributor of drug interactions on account of its playing a major role in the metabolism of drugs and other substances that enter the body. A significant amount of deaths occur due to diseases aggravated by the toxic action of therapeutic substances on the liver. There are not many measures to combat the hepatotoxicity of drugs except for reducing the dose, stopping the drug suspected to be responsible and changing the drugs substituting it with another drug of the same pharmacological action. Plant extracts have a wide range of medicinal actions, and throughout history, they have been used to treat many different types of diseases. In the treatment of many diseases, antioxidant therapy plays a key role, so current research is now directed towards finding naturally occurring hepatoprotective of plant origin. The medicinal properties of plant may be due to the presence of phytochemicals like tannins, flavonoids, terpenoids and steroids. Presently it has become a source of medicine for healing human and animal diseases. Hence, in order to contribute further to the knowledge of Indian traditional medicine, and its rich history. Hepatoprotective activity of hydroalcoholic extract of Syzygium aeoranthum fruits against Isoniazid-induced hepatic damage in Wistar albino rats was observed at two different doses, 200 and 400 mg/kg body weight. The healthy control, disease control, and standard drug Silymarin-treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALKP, Serum Bilirubin and other metabolic parameters like total cholesterol, HDL-cholesterol were evaluated in all the experimental groups. The changes in liver function parameters were significant in comparison to disease control group and the observed efficacy was comparable to standard drug. The efficacy of hydroalcoholic extract of Syzygium aeoranthum fruits was found to be dose dependent. The histopathology study of liver also supports the presence of hepatoprotective activity in Syzygium aeoranthum fruits by showing improved cytoarchitecture of liver cells in the treated groups.

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Deepak kumar, Mr. Dhyanendra Singh, Mrs. Pranali Mishra, & Dr.Vishal Gupta (April-2023). PHARMACOLOGICAL EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF FRUITS EXTRACT OF SYZYGIUM AEORANTHUM. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(4), b350-b358. https://ijnrd.org/papers/IJNRD2304138.pdf

Volume 8 Issue 4, April-2023

Pages : b350-b358

Paper Reg. ID: IJNRD_190653

Published Paper Id: IJNRD2304138

Research Area: Engineering

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