INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Published Paper Details
Paper Title:
Analytical Method Development and Validation for Simultaneous estimation of Metformin Hydrochloride and Empagliflozin by RP-HPLC in Bulk and it’s Tablet dosage form
Metformin is a class of drug called Biguanides. It is used to control high blood sugar in type 2 diabetes ,hence it help to prevent kidney damage, blindness, nerve damage, sexual problems, while in case of Empagliflozin it is belong to class sodium glucose co- transporter SGLT-2 inhibitor it lowers blood sugar by causing kidney to get rid of more glucose in the urine. The present work is based on excludation of buffer solution in mobile phase and use of cheap solvent in development of cost effective method.
Result: The Chromatographic separation was achieved on Chemsil C18 column used as stationary phase and Methanol : Water (65:35% v/v) used as mobile phase. The flow rate was 1ml/min and the absorbance was monitored at 227nm. Metformin Hydrochloride and Empagliflozin was eluted at 2.273min and 4.117min. The procedure and capabilities were evaluated against system suitability, linearity, precision ,accuracy, LOD,LOQ and Robustness as per ICH Q2 (R1) guidelines. The method shows good linearity ( R2=0.9992 and 0.9996)
"Analytical Method Development and Validation for Simultaneous estimation of Metformin Hydrochloride and Empagliflozin by RP-HPLC in Bulk and it’s Tablet dosage form", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 8, page no.340-355, August-2022, Available :http://www.ijnrd.org/papers/IJNRD2208039.pdf
Downloads:
000118761
ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Facebook Twitter Instagram LinkedIn