INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Pregabalin (Preg) and Nortriptyline hydrochloride (Nor) were determined in tablet dosage form using simple, rapid, specific, accurate, economical, and precise RP-HPLC techniques that were developed and validated as per ICH guidelines. BDS Hypersil C18 column (150mm, 4.6mm, and 2.5µm) and buffer: methanol pH4.2 0.1% (80:20v/v) as mobile phase was utilized to separate the samples using chromatography, which was detected by UV light at 235 nm. Pregabalin and Nortriptyline hydrochloride were exposed to acid-base hydrolytic, photolytic, and oxidative stress conditions as part of trials to force degradation of the drugs. Linearity, accuracy, precision, LOD, and LOQ of the method have all been validated. The retention time for Pregabalin and Nortriptyline hydrochloride were found to be 2.281 min and 7.073 min respectively.
Keywords:
Nortriptyline, Pregabalin, Method development, Validation, Quality by design, Force degradation
Cite Article:
"DEVELOPMENT OF SIAM FOR NORTRIPTYLINE AND PREGABALIN BY RP-HPLC", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 4, page no.d51-d60, April-2023, Available :http://www.ijnrd.org/papers/IJNRD2304308.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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