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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | In-Silico STUDIES, CHARACTERIZATION, ADMET PREDICTION, AND MOLECULAR DOCKING OF VIGNA VEXILLATA CONSTITUENTS AND THEIR CNS STIMULANT ACTIVITY |
| Authors Name: | Vaibhav N. Mohare , Alpana J. Asnani , Swapnja B. Gunjarkar , Samiksha R. Mehare , Monika W. Parate |
| Download E-Certificate: | Download |
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IJNRD_193651
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| Published Paper Id: | IJNRD2305067 |
| Published In: | Volume 8 Issue 5, May-2023 |
| DOI: | |
| Abstract: | There have been several studies about the bioactivities of the seeds from the Vigna genus, which are significant food sources. The entire V. vexillata plant, including the flowers and pods, was air-dried and pulverized. Methanol was then extracted under reflux and concentrated to create a dark brown syrup. The binding affinity and interactions with amino acids of phytochemicals were evaluated. Target protein protein homology modeling, protein structure validation, and energy minimization were all completed. A comparative in-silico docking analysis with the standard drug was conducted using phytochemicals that had been mentioned in the literature as having properties related to CNS stimulant activities. These phytochemicals were studied for their absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties and those that passed ADMET filters. Using AutoDock Vina, a preliminary docking study was performed, then AutoDock 4.2.6 and SwissDock were used to validate the results. |
| Keywords: | Vigna; Isoflavone, Molecular Docking, PyRx Vina auto dock, Chemsketch, ADMET Prediction. |
| Cite Article: | "In-Silico STUDIES, CHARACTERIZATION, ADMET PREDICTION, AND MOLECULAR DOCKING OF VIGNA VEXILLATA CONSTITUENTS AND THEIR CNS STIMULANT ACTIVITY", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.a526-a536, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305067.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2305067 Registration ID: 193651 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: a526-a536 Country: NAGPUR, MAHARASHTRA, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2305067 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2305067 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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