INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
The carbohydrate molecules forms a variety of natural products named “glycoconjugates – key components of different biological processes”. The challenge lies in preparation of bulk quantities of these organics for industrial application and processes. The monosaccharide as raw material to synthesize glycoconjugates are available in large quantities so as to oligomerise these monosaccharides.The chiral nature of monosaccharide has made them suitable to use as starting material also for the synthesis of compounds other than glycoconjugates. Glycal a cyclic enol ether derivatives of sugars can be formed as pyranose (six-membered) or furanose (five-membered) rings, depending on the monosaccharide used as a starting material to synthesize the glycal which can be transformed to an exo-glycal. More recently, glycals have also been shown to be excellent starting substrates for library development and preparation of exo - glycals. The Fischer–Zach method has been one of the most popular methods for synthesizing glycals. It has been suggested that heterolytic cleavage of the carbon–halogen bond occurs under these acidic conditions ,initially to give an anomeric carbocation that, after taking two electrons from the zinc atom, generates a transient carbanion that evolves through the splitting off of an acetate anion. In present study we have investigated the role of other reducing agents in this transformation with glycosyl halides include sodium and potassium metal, sodium naphthalide, zinc/silver graphite, aluminum amalgam, SmI2, potassium graphite ,lithium/ammonia, chromium(II), zinc/base, cobalt(II), and titanium(III). A glucal derivative has also been prepared by introduction of a halogen atom at C-2, followed by a reductive elimination reaction in the opposite sense.
"The Synthesis of Medicinally Important Pharma Molecules from Carbohydrates Building Blocks", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.e133-e148, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305414.pdf
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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