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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Effect of Ethanolic Leaf Extract of Euphorbia thymifolia on Some Biochemical Indices of Alloxan-Induced Diabetic Male Albino Wistar Rats. |
| Authors Name: | Elijah Udo Afangideh , Rosemary Francis usen , Sifon Saviour Udom |
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IJNRD_198589
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| Published Paper Id: | IJNRD2306534 |
| Published In: | Volume 8 Issue 6, June-2023 |
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| Abstract: | Abstract The study investigated the effect of ethanolic leaf extract of Euphorbia thymifolia on some biochemical indices of alloxan-induced diabetic male albino wistar rats. Albino rats weighing 106 – 129g were randomly assigned 6 groups of 5 rats each. Diabetes was induced in groups 1-5 rats through intraperitoneal injection of 150mg/kg body weight of alloxan monohydrate. Groups 1, 2, 3 and 4 were treated with 500, 1000,1500mg/kg of Euphorbia thymifolia and 50mg/kg of metformin respectively. Groups 5 and 6 served as diabetic control and normal control respectively. Treatment lasted for 21days. All rats were given free access to feed and water ad libitum. Animals were sacrificed and blood obtained via cardiac puncture for biochemical assay. Treatment with Euphorbia thymifolia extract revealed a significant decrease (p<0.05) in blood glucose when compared to the untreated group. CAT, SOD and GPx activities were significantly lower (p<0.05) in untreated diabetic rats when compared to the normal. Serum TC, TG and LDL-C showed a significant increase (p<0.05) with a concomitant decrease in HDL-C in untreated diabetic rats. Treatment with Euphorbia thymifolia significantly ameliorated these biochemical indices. This suggest that Euphorbia thymifolia possess therapeutic potentials and could be applied for the management of diabetes and its associated complications. |
| Keywords: | Euphorbia thymifolia, Diabetes, alloxan, antioxidant enzymes, lipid profile |
| Cite Article: | "Effect of Ethanolic Leaf Extract of Euphorbia thymifolia on Some Biochemical Indices of Alloxan-Induced Diabetic Male Albino Wistar Rats.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 6, page no.f341-f350, June-2023, Available :http://www.ijnrd.org/papers/IJNRD2306534.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2306534 Registration ID: 198589 Published In: Volume 8 Issue 6, June-2023 DOI (Digital Object Identifier): Page No: f341-f350 Country: Ikot Ekpene, Akwa Ibom State, Nigeria Research Area: Biological Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2306534 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2306534 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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