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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | PROCESS VALIDATION OF COATED LARIAGO TABLET |
| Authors Name: | VAIBHAV BURHANPURKAR |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_201499
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| Published Paper Id: | IJNRD2307194 |
| Published In: | Volume 8 Issue 7, July-2023 |
| DOI: | |
| Abstract: | Chloroquine was used as a prophylactic agent against malaria, and more recently as a mild immunosuppressive. However, due to lengthy treatment periods, adverse effects have become apparent, which included retinopathy. The structurally related hydroxychloroquine is less toxic, thought to be owing to a lower tissue accumulation in melanin rich areas. This study primarily focused on quantifying melanin binding between chloroquine and hydroxychloroquine at physiological pH to investigate the potential link between binding and reported toxicity. In addition, for the first time this study quantified the actual extent of adsorption of chloroquine and hydroxychloroquine to melanin and examined the desorption profile of both drugs from melanin to demonstrate the affinity between the pigment and the solutes. The results suggest that there is a difference between the adsorption affinities of chloroquine and hydroxychloroquine, potentially explaining the differences in bioaccumulation in retinal tissue. In addition, both solutes displayed a strong physical attraction to the absorbent |
| Keywords: | CHLOROQUINE |
| Cite Article: | "PROCESS VALIDATION OF COATED LARIAGO TABLET", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 7, page no.b849-b854, July-2023, Available :http://www.ijnrd.org/papers/IJNRD2307194.pdf |
| Downloads: | 000118755 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2307194 Registration ID: 201499 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: b849-b854 Country: NAVI MUMBAI, MAHARASHTRA, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2307194 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2307194 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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