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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | DESIGN, DEVELOPMENT AND EVALUATION OF NITRENDIPINE LOADED SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM |
| Authors Name: | ABHISHEK DUBEY , KAUSHALYA BAINS |
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| Author Reg. ID: |
IJNRD_200614
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| Published Paper Id: | IJNRD2307243 |
| Published In: | Volume 8 Issue 7, July-2023 |
| DOI: | |
| Abstract: | The aim of this work was to improve the in-vitro dissolution of Nitrendipine through development of self nanoemulsifying capsules. Nitrendipine is an anti-hypertensive agent used to treat mild to moderate Hypertension. It has poor oral bioavailability so self nanoemulsifying drug delivery of Nitrendipine enhances its bioavailabilty. For the construction of pseudo ternary phase diagram the oil phase (Ethyl oleate/ Olive oil/ Castor oil), surfactant, co-surfactant (Tween 80 and PEG 400) and aqueous phase (Distilled water) was selected. Surfactant and co-surfactant (Smix) were mixed at (3:1) ratio and prepared phase diagram. The Liquid-SNEDDS (F1-F3) were prepared by using different ratios of Ethyl oleate (oil phase), Tween 80 (Surfactant) and PEG 400 (Co-surfactant) based on Ternary Phase Diagram. The prepared formulation will be characterized for several parameters such as physical appearance, pH, Scanning Electron Microscopy, Drug content, Drug entrapment efficiency, in vitro drug release, and stability studies. At the end it can be concluded that the optimized formula were able to introduce Nitrendipine successfully in SNEDDS to enhance the oral bioavailability of Nitrendipine. |
| Keywords: | Nanoemulsion, Nitendipine, Self nanoemulsifying drug delivery system(SNEDDS), Ternary Phase Diagram, Surfactants. |
| Cite Article: | "DESIGN, DEVELOPMENT AND EVALUATION OF NITRENDIPINE LOADED SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 7, page no.c396-c408, July-2023, Available :http://www.ijnrd.org/papers/IJNRD2307243.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2307243 Registration ID: 200614 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: c396-c408 Country: Sirmaur, Himachal Pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2307243 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2307243 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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