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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | REACTIVE OXYGEN SPECIES (ROS): A BRIGHT MOON TOWARDS CANCER THERAPY- A Review |
| Authors Name: | Pooja. P. Dahale , Dr. Pawar Anil Raosaheb |
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IJNRD_201301
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| Published Paper Id: | IJNRD2307268 |
| Published In: | Volume 8 Issue 7, July-2023 |
| DOI: | |
| Abstract: | Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer effect of these chemotherapeutics is due to the induction of oxidative stress and ROS-mediated cell injury in cancer. Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required for several cellular functions, including gene expression. The production of ROS is elevated in tumor cells as a consequence of increased metabolic rate, gene mutation and relative hypoxia, and excess ROS are quenched by increased antioxidant enzymatic and nonenzymatic pathways in the same cells. Our review will emphasize the molecular mechanisms useful for the development of therapeutic strategies that are based on modulating ROS levels to treat cancer. In the late 1950's free radicals (FR) and antioxidants were almost unheard of in the clinical and biological sciences but chemists had known about them for years in the context of radiation, polymer and combustion technology. |
| Keywords: | Cancer, Reactive oxygen species (ROS), Free Radicals (FR), Signaling pathways, redox-homeostasis. |
| Cite Article: | "REACTIVE OXYGEN SPECIES (ROS): A BRIGHT MOON TOWARDS CANCER THERAPY- A Review", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 7, page no.c690-c698, July-2023, Available :http://www.ijnrd.org/papers/IJNRD2307268.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2307268 Registration ID: 201301 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: c690-c698 Country: pune, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2307268 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2307268 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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