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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Synthesis of some Newer Pyrimidine Derivatives as Antimalarial Agents |
| Authors Name: | Sanjeev Saket , Dr. Parul Mehta , Dr. Govind Nayak , Mr. Mukesh Pawar |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_201846
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| Published Paper Id: | IJNRD2307285 |
| Published In: | Volume 8 Issue 7, July-2023 |
| DOI: | |
| Abstract: | Five compounds were synthesized using the synthetic scheme that was derived from the works of Panda and Ram. The synthesis of 3, 4-dihydropyrimidine was performed by using substituted benzaldehyde, urea and ethylacetoacetate as depicted in the section below by Biginelli condensation. The hydrazide derivative of the dihydropyrimidine-2-one was synthesized by the treatment of the product of step 1 by hydrazine hydrate in presence of ethanol with catalytic amount of concentrated sulfuric acid. The triazolo derivatives were synthesized by the condensation of the hydrazide derivative, ammonium acetate and an aldehyde in the presence of acetic acid. The product precipitated on neutralization with ammonia solution. Alkylation of the pyrimidine derivatives obtained in the step 3 was accomplished by the treatment with alkyl halide and K2CO3 in presence of DMF. The compounds were obtained in the yield of 68 to 80% and were off white to pale yellow in color. All the compounds were soluble in water and DMSO, slightly soluble in methanol and insoluble in chloroform. |
| Keywords: | Docking, Pyrimidine, Uracil, Thymidine, Cytosine and Antimalarial activity |
| Cite Article: | "Synthesis of some Newer Pyrimidine Derivatives as Antimalarial Agents", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 7, page no.c869-c878, July-2023, Available :http://www.ijnrd.org/papers/IJNRD2307285.pdf |
| Downloads: | 000118749 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2307285 Registration ID: 201846 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: c869-c878 Country: Bhopal, Madhya Pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2307285 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2307285 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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