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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | RP-HPLC method for the simultaneous estimation of Saxagliptin and Dapagliflozin in combined pharmaceutical dosage form |
| Authors Name: | P. Seetharamaiah , Nagaraju Pappula , JVLN. Seshagiri Rao , D. Gowrisankar |
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IJNRD_202171
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| Published Paper Id: | IJNRD2307355 |
| Published In: | Volume 8 Issue 7, July-2023 |
| DOI: | |
| Abstract: | A simple, accurate, precise method was developed for the simultaneous estimation of Saxagliptin and Dapagliflozin in Tablet dosage form. Chromatogram was run through standard altima C18 column (150 ×4.6 mm, 5) The Mobile phase containing Phosphate buffer: Acetonitrile in the ratio 60:40 v/v. The solution was pumped through the column at a flow rate of 1 ml/min. The column temperature was maintained at 30°C. Optimized wavelength selected was 222 nm. Retention time of Saxagliptin and Dapagliflozin were found to be 2.18 min and 2.74 min. % RSD of the Saxagliptin and Dapagliflozin were found to be 0.7 and 0.7 respectively. % Recovery was obtained as 99.19% and 99.06% for Saxagliptin and Dapagliflozin respectively. LOD, LOQ values obtained from regression equations of Saxagliptin and Dapagliflozin were 0.01, 0.03 and 0.04, 0.13 respectively. Regression equation of Saxagliptin is y = 14803x + 786.4 and y =13944x+4370.2 of Dapagliflozin. So the developed method was simple and economical that can be applied successfully for simultaneous estimation of both Saxagliptin and Dapagliflozin in bulk and combined tablet formulation. |
| Keywords: | Saxagliptin, Dapagliflozin, RP-HPLC, Validation, Simultaneous estimation |
| Cite Article: | "RP-HPLC method for the simultaneous estimation of Saxagliptin and Dapagliflozin in combined pharmaceutical dosage form", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 7, page no.d478-d488, July-2023, Available :http://www.ijnrd.org/papers/IJNRD2307355.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2307355 Registration ID: 202171 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: d478-d488 Country: -, -, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2307355 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2307355 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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