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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | THE PROTECTIVE EFFECT OF CISPLATIN NEPHROTOXICITY IN MICE ON MELATONIN AND GLUTATHIONE |
| Authors Name: | AJAY KUMAR , NEERAJ KUMAR |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_203994
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| Published Paper Id: | IJNRD2308323 |
| Published In: | Volume 8 Issue 8, August-2023 |
| DOI: | |
| Abstract: | Cisplatin Nephrotoxicity Several theories have been put forth, but one that stands out is oxidative stress (including glutathione depletion and lipid peroxide generation). This study explains how the antioxidant system contributes to the nephrotoxicity caused by cisplatin and the nephroprotection provided by melatonin. Albino mice (BALB/c) were intravenously injected with: 1) Vehicle management 2) a single 6.5 mg/kg dosage CP group for cisplatin: 3) Melatonin 10 mg/kg for five days following CP injection. CPM team: 4) five days of melatonin (10 mg/kg) before and after CP injection The MCPM group: 5) M group received 10 mg/kg of melatonin daily for 5 days. In order to measure serum creatinine and blood urea nitrogen (BUN) mice were slaughtered five days after receiving CP injections |
| Keywords: | Cisplatin nephrotoxicity lipid peroxidation antioxidant and Glutathione |
| Cite Article: | "THE PROTECTIVE EFFECT OF CISPLATIN NEPHROTOXICITY IN MICE ON MELATONIN AND GLUTATHIONE", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 8, page no.d44-d51, August-2023, Available :http://www.ijnrd.org/papers/IJNRD2308323.pdf |
| Downloads: | 000118750 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2308323 Registration ID: 203994 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: d44-d51 Country: HAPUR, UTTAR PRADESH, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2308323 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2308323 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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